Basic Information:

  VIRBase ID:  

HHID00026641

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:  MIMAT0000421          HMOX1:  NM_002133     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-122-5p	HMOX1
miRBase Accession/Entrez ID	MIMAT0000421	3162
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bK286B10//HMOX1D//HO-1//HSP32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-122-5p	rs1258166649 chr18:58451088    T/C rs1426570658 chr18:58451093    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HMOX1	chr22:35787954(+) A-I      intronic chr22:35784679(+) A-I      intronic chr22:35788097(+) A-I      intronic chr22:35788149(+) A-I      intronic chr22:35788106(+) A-I      intronic chr22:35788102(+) A-I      intronic chr22:35784669(+) A-I      intronic chr22:35787541(+) A-I      intronic chr22:35784711(+) A-I      intronic chr22:35785510(+) A-I      intronic chr22:35785529(+) A-I      intronic chr22:35785535(+) A-I      intronic chr22:35787308(+) A-I      intronic chr22:35787342(+) A-I      intronic chr22:35787420(+) A-I      intronic chr22:35787446(+) A-I      intronic chr22:35787699(+) A-I      intronic chr22:35787717(+) A-I      intronic chr22:35787944(+) A-I      intronic chr22:35787963(+) A-I      intronic chr22:35788007(+) A-I      intronic chr22:35788096(+) A-I      intronic chr22:35788023(+) A-I      intronic chr22:35788174(+) A-I      intronic chr22:35788167(+) A-I      intronic chr22:35785492(+) A-I      intronic chr22:35788137(+) A-I      intronic chr22:35785708(+) A-I      intronic chr22:35784186(+) A-I      intronic chr22:35787642(+) A-I      intronic chr22:35788849(+) A-I      intronic chr22:35784324(+) A-I      intronic chr22:35788031(+) A-I      intronic chr22:35786496(+) A-I      intronic chr22:35785601(+) A-I      intronic chr22:35785575(+) A-I      intronic chr22:35785602(+) A-I      intronic chr22:35787998(+) A-I      intronic chr22:35788008(+) A-I      intronic chr22:35785637(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HMOX1	chr22:35790022(+) T-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMOX1	chr22:35777264-35777265(+) m6A exon//intron       24284625//24981863//26404942 chr22:35777300-35777301(+) m6A exon//intron       24981863//26404942 chr22:35779181-35779182(+) m6A CDS//exon       24981863//26404942 chr22:35782807-35782808(+) m6A CDS//exon       26404942 chr22:35782999-35783000(+) m6A CDS       24284625//25456834//26404942 chr22:35783092-35783093(+) m6A CDS//exon       24284625//25456834//26404942 chr22:35783145-35783146(+) m6A CDS//exon       26404942 chr22:35785899-35785900(+) m6A CDS//exon       24284625//26404942 chr22:35786004-35786005(+) m6A exon//intron       24284625 chr22:35789477-35789478(+) m6A CDS       24284625//26404942 chr22:35789621-35789622(+) m6A 3'UTR       24284625//24981863//26404942 chr22:35789799-35789800(+) m6A 3'UTR       26404942 chr22:35789868-35789869(+) m6A 3'UTR       26404942 chr22:35789894-35789895(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-122-5p	Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196 Cytoplasm Huh-7 cells     29486652 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Huh-7 cells     26304123 Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950 Exosome B cell line (Raji)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|Chronic lymphocytic leukemia cells     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196 Nucleus Nasopharyngeal carcinoma cells     20498841 Polysome Human cervical cancer cell line (HeLa)     25609084
	HMOX1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-122-5p
Interactor2: HMOX1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qPCR//RT-PCR//Western blot
Support Database	VIRmiRNA

References:

[1]PMID	20633528	Target region	None
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Hepatoma cells	Interactor2 expression	None
Description	In this study we examined the effects of antisense inhibition of miR-122 and transfection of a miR-122 mimic on HBV expression in hepatoma cells. The over-expression of miR-122 inhibited HBV expression, whereas the depletion of endogenous miR-122 resulted in increased production of HBV in transfected cells. We further found that the down-regulation of Heme oxygenase-1 (HO-1) by miR-122 plays a negative role in the miR-122-mediated inhibition of viral expression. Our study demonstrates the anti-HBV activity of miR-122, suggesting that therapies that increase miR-122 and HO-1 may be an effective strategy to limit HBV replication.

[2]PMID	21565290	Target region	None
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Hepatoma cells	Interactor2 expression	None
Description	We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).