Detail Information

Basic Information:


  VIRBase ID:  

HHID00026638

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9933

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:           PTTG1IP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p PTTG1IP
miRBase
Accession/Entrez ID		 MIMAT0000421 754
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C21orf1//C21orf3//PBF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PTTG1IP
chr21:46284395(-) A-I      intronic
chr21:46284435(-) A-I      intronic
chr21:46272150(-) A-I      intronic
chr21:46272279(-) A-I      intronic
chr21:46284380(-) A-I      intronic
chr21:46272124(-) A-I      intronic
chr21:46272126(-) A-I      intronic
chr21:46272135(-) A-I      intronic
chr21:46284191(-) A-I      intronic
chr21:46272267(-) A-I      intronic
chr21:46272270(-) A-I      intronic
chr21:46272264(-) A-I      intronic
chr21:46280887(-) A-I      intronic
chr21:46280094(-) A-I      intronic
chr21:46280898(-) A-I      intronic
chr21:46280851(-) A-I      intronic
chr21:46272253(-) A-I      intronic
chr21:46290244(-) A-I      intronic
chr21:46290226(-) A-I      intronic
chr21:46272136(-) A-I      intronic
chr21:46272174(-) A-I      intronic
chr21:46272203(-) A-I      intronic
chr21:46280830(-) A-I      intronic
chr21:46280888(-) A-I      intronic
chr21:46272265(-) A-I      intronic
chr21:46272276(-) A-I      intronic
chr21:46272300(-) A-I      intronic
chr21:46280890(-) A-I      intronic
chr21:46272391(-) A-I      intronic
chr21:46273218(-) A-I      intronic
chr21:46273229(-) A-I      intronic
chr21:46273241(-) A-I      intronic
chr21:46273253(-) A-I      intronic
chr21:46280070(-) A-I      intronic
chr21:46280227(-) A-I      intronic
chr21:46280827(-) A-I      intronic
chr21:46280946(-) A-I      intronic
chr21:46280984(-) A-I      intronic
chr21:46284388(-) A-I      intronic
chr21:46272363(-) A-I      intronic
chr21:46273255(-) A-I      intronic
chr21:46273258(-) A-I      intronic
chr21:46273347(-) A-I      intronic
chr21:46273366(-) A-I      intronic
chr21:46273371(-) A-I      intronic
chr21:46277171(-) A-I      intronic
chr21:46277334(-) A-I      intronic
chr21:46277361(-) A-I      intronic
chr21:46280054(-) A-I      intronic
chr21:46277307(-) A-I      intronic
chr21:46290211(-) A-I      intronic
chr21:46272368(-) A-I      intronic
chr21:46272125(-) A-I      intronic
chr21:46272266(-) A-I      intronic
chr21:46289413(-) A-I      intronic
chr21:46282395(-) A-I      intronic
chr21:46280245(-) A-I      intronic
chr21:46272257(-) A-I      intronic
chr21:46289505(-) A-I      intronic
chr21:46280857(-) A-I      intronic
chr21:46284423(-) A-I      intronic
chr21:46282322(-) A-I      intronic
chr21:46273160(-) A-I      intronic
chr21:46272225(-) A-I      intronic
chr21:46284472(-) A-I      intronic
chr21:46272194(-) A-I      intronic
chr21:46273311(-) A-I      intronic
chr21:46290212(-) A-I      intronic
chr21:46284517(-) A-I      intronic
chr21:46272329(-) A-I      intronic
chr21:46280208(-) A-I      intronic
chr21:46272347(-) A-I      intronic
chr21:46272165(-) A-I      intronic
chr21:46284408(-) A-I      intronic
chr21:46272127(-) A-I      intronic
chr21:46284568(-) A-I      intronic
chr21:46277319(-) A-I      intronic
chr21:46273301(-) A-I      intronic
chr21:46280856(-) A-I      intronic
chr21:46277302(-) A-I      intronic
chr21:46290181(-) A-I      intronic
chr21:46289493(-) A-I      intronic
chr21:46280953(-) A-I      intronic
chr21:46290287(-) A-I      intronic
chr21:46280990(-) A-I      intronic
chr21:46280896(-) A-I      intronic
chr21:46280160(-) A-I      intronic
chr21:46290199(-) A-I      intronic
chr21:46282268(-) A-I      intronic
chr21:46277147(-) A-I      intronic
chr21:46272301(-) A-I      intronic
chr21:46284593(-) A-I      intronic
chr21:46289487(-) A-I      intronic
chr21:46272315(-) A-I      intronic
chr21:46282191(-) A-I      intronic
chr21:46284420(-) A-I      intronic
chr21:46280892(-) A-I      intronic
chr21:46272377(-) A-I      intronic
chr21:46272261(-) A-I      intronic
chr21:46280895(-) A-I      intronic
chr21:46277268(-) A-I      intronic
chr21:46273233(-) A-I      intronic
chr21:46280119(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PTTG1IP
chr21:46272165(-) A-I intron -    15342557
chr21:46272190(-) A-I intron -    15342557
chr21:46272235(-) A-I intron -    15342557   //15258596
chr21:46272256(-) A-I intron -    15342557   //15258596
chr21:46272257(-) A-I intron -    15342557   //15258596
chr21:46272266(-) A-I intron -    15342557   //15258596
chr21:46272290(-) A-I intron -    15342557   //15258596
chr21:46289493(-) A-I intron -    21960545   //22327324
chr21:46289481(-) A-I intron -    21960545
chr21:46269601(-) G-C exon 3'UTR    21725310
chr21:46272235(-) A-G intron -    22484847
chr21:46280856(-) A-G intron -    22484847
chr21:46280922(-) A-G intron -    22484847
chr21:46280953(-) A-G intron -    22484847
chr21:46284401(-) A-G intron -    22484847
chr21:46289481(-) A-G intron -    22484847
chr21:46289486(-) A-G intron -    22484847
chr21:46289487(-) A-G intron -    22484847
chr21:46289493(-) A-G intron -    22484847
chr21:46290181(-) A-G intron -    22484847
chr21:46290199(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PTTG1IP
chr21:46269572-46269573(-) m6A 3'UTR       27773535
chr21:46269589-46269590(-) m6A 3'UTR       27773535
chr21:46269657-46269658(-) m6A 3'UTR       24284625//28052920//27773535//22575960//22608085
chr21:46269776-46269777(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr21:46269786-46269787(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr21:46269800-46269801(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46269825-46269826(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46269933-46269934(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270013-46270014(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270022-46270023(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270033-46270034(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270065-46270066(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270081-46270082(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270090-46270091(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:46270169-46270170(-) m6A 3'UTR       24284625//24209618//26404942//22608085
chr21:46270417-46270418(-) m6A 3'UTR       27773536
chr21:46270773-46270774(-) m6A 3'UTR       26404942
chr21:46270803-46270804(-) m6A 3'UTR       26404942
chr21:46270834-46270835(-) m6A 3'UTR       24284625//26404942
chr21:46270891-46270892(-) m6A 3'UTR       24284625
chr21:46270941-46270942(-) m6A 3'UTR       24284625//26404942//27773535
chr21:46271034-46271035(-) m6A 3'UTR       24284625//24981863//26404942//27773535
chr21:46271041-46271042(-) m6A 3'UTR       24284625//24981863//26404942//27773535
chr21:46271070-46271071(-) m6A 3'UTR       24284625//24981863//27773535
chr21:46271148-46271149(-) m6A 3'UTR       24284625//24981863//27773535
chr21:46271319-46271320(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr21:46271339-46271340(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//22608085
chr21:46271368-46271369(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//22608085
chr21:46271386-46271387(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//22608085
chr21:46271425-46271426(-) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//27773535//27371828//22608085
chr21:46271502-46271503(-) m6A CDS       24284625//24981863//26404942//27773535//27371828
chr21:46271523-46271524(-) m6A CDS       24284625//24981863//26404942//27773535//27371828
chr21:46275149-46275150(-) m6A CDS//exon//intron       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536
chr21:46275154-46275155(-) m6A CDS//exon//intron       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536
chr21:46276122-46276123(-) Y CDS//exon//intron       26075521
chr21:46276167-46276168(-) m6A CDS//exon//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536
chr21:46276234-46276235(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960
chr21:46276275-46276276(-) m6A CDS//exon//intron       24284625//24981863
chr21:46285528-46285529(-) m1A exon//intron       26863410
chr21:46293591-46293592(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084
PTTG1IP
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: PTTG1IP

Evidence Support:


Strong-Evidence IHC//Luciferase reporter assay//Northern blot//qPCR//Western blot
Support Database ViRBase

References:


PMID 23221562 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells//Huh7 cells//L02 cells//SK-Hep-1 cells Interactor2 expression Upregulation
Description We next identified pituitary tumor-transforming gene 1 (PTTG1) binding factor (PBF) as a target of miR-122 and demonstrated that HBV replication causes an obvious increase in PBF levels. Furthermore, we observed that the miR-122 levels were decreased and PBF was upregulated in chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC).

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