Detail Information

Basic Information:


  VIRBase ID:  

HHID00026595

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-5p:           MYC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-5p MYC
miRBase
Accession/Entrez ID		 MIMAT0000067 4609
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bHLHe39//c-Myc//MRTL//MYCC

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-5p
rs1156338084 chr9:94176368    T/C
rs1421386283 chr9:94176365    T/C

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MYC
chr8:128752212(+) C-T intron -    22484847
chr8:128752228(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYC
chr8:128747856-128747857(+) m6A 5'UTR       24284625
chr8:128747998-128747999(+) m6A 5'UTR       24284625
chr8:128748018-128748019(+) m6A 5'UTR       24284625
chr8:128748315-128748316(+) m6A 5'UTR//intron       24284625//24981863
chr8:128748596-128748597(+) Y 5'UTR//intron       26075521
chr8:128748673-128748674(+) m6A 5'UTR//intron       24284625//24981863//26404942//22575960
chr8:128748711-128748712(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748776-128748777(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748798-128748799(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748864-128748865(+) m6A 5'UTR//CDS       24284625//24981863//22575960
chr8:128750539-128750540(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22575960
chr8:128750596-128750597(+) m6A CDS       24284625//24981863//26404942//22575960
chr8:128750761-128750762(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750833-128750834(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750842-128750843(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750874-128750875(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750887-128750888(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750902-128750903(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750980-128750981(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128750995-128750996(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128751142-128751143(+) m6A CDS       24284625//22575960
chr8:128751237-128751238(+) m6A CDS       24284625//22575960
chr8:128752648-128752649(+) m6A CDS       24284625//22575960
chr8:128752750-128752751(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr8:128752836-128752837(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752866-128752867(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752885-128752886(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752886-128752887(+) Cm CDS       -
chr8:128752929-128752930(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752955-128752956(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753040-128753041(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753136-128753137(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753158-128753159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753167-128753168(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753173-128753174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753179-128753180(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753190-128753191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753261-128753262(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753316-128753317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753341-128753342(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753356-128753357(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:128753373-128753374(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Human milk     28688106
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Plasma     24937531
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
MYC
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7f-5p
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug sensitive
Artelastin 399488 Drug resistant
Salarin C 24867082 Drug resistant
Epilactose 128037 Drug resistant
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
organosulfur compound - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7f-5p
Formaldehyde 712 Drug interaction    RC00000304
Bisphenol A 6623 Drug interaction    RC00000311
Gemcitabine 60750 Drug interaction    RC00000315
Estradiol 5757 Drug interaction    RC00000310
Imatinib 5291 Drug interaction    RC00000309
Cholecalciferol 5280795 Drug interaction    RC00000319
Decitabine 451668 Drug interaction    RC00000318
Oleic acid 445639 Drug interaction    RC00000317
Docosahexaenoic acid 445580 Drug interaction    RC00000316
Letrozole 3902 Drug interaction    RC00000308
5-Fluorouracil 3385 Drug interaction    RC00000307
Doxorubicin 31703 Drug interaction    RC00000314
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000306
Verapamil 2520 Drug interaction    RC00000305
Arsenic trioxide 14888 Drug interaction    RC00000313
Hesperidin 10621 Drug interaction    RC00000312
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000320

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-5p
Interactor2: MYC

Evidence Support:


Strong-Evidence IHC//qRT-PCR//Western blot
Support Database VIRmiRNA

References:


[1]PMID 20033209 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description Real-time RT-PCR showed the expression of let-7a was increased significantly in A549-let-7a cells-injected group, compared with A549-control cells-injected group and A549 cells-injected group (P < 0.01). In the xenografts of A549-let-7a cells-injected group, a significant depression in tumor weight (P < 0.05) and significant decrease of k-Ras and c-Myc protein were observed (P < 0.01), compared to A549 cells-injected group and A549-control cells-injected group.
[2]PMID 21565290 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

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