Detail Information

Basic Information:


  VIRBase ID:  

HHID00026594

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-5p:           CASP3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-5p CASP3
miRBase
Accession/Entrez ID		 MIMAT0000067 836
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CPP32//CPP32B//SCA-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-5p
rs1156338084 chr9:94176368    T/C
rs1421386283 chr9:94176365    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CASP3
chr4:185563395(-) A-I      intronic
chr4:185563394(-) A-I      intronic
chr4:185563384(-) A-I      intronic
chr4:185563373(-) A-I      intronic
chr4:185563404(-) A-I      intronic
chr4:185563238(-) A-I      intronic
chr4:185563248(-) A-I      intronic
chr4:185563256(-) A-I      intronic
chr4:185563258(-) A-I      intronic
chr4:185563263(-) A-I      intronic
chr4:185563366(-) A-I      intronic
chr4:185563267(-) A-I      intronic
chr4:185563281(-) A-I      intronic
chr4:185563282(-) A-I      intronic
chr4:185563287(-) A-I      intronic
chr4:185558634(-) A-I      intronic
chr4:185558588(-) A-I      intronic
chr4:185558356(-) A-I      intronic
chr4:185564752(-) A-I      intronic
chr4:185564777(-) A-I      intronic
chr4:185564768(-) A-I      intronic
chr4:185564626(-) A-I      intronic
chr4:185563358(-) A-I      intronic
chr4:185557396(-) A-I      intronic
chr4:185563253(-) A-I      intronic
chr4:185557349(-) A-I      intronic
chr4:185558689(-) A-I      intronic
chr4:185558232(-) A-I      intronic
chr4:185558615(-) A-I      intronic
chr4:185551739(-) A-I      intronic
chr4:185558568(-) A-I      intronic
chr4:185563319(-) A-I      intronic
chr4:185566909(-) A-I      intronic
chr4:185566948(-) A-I      intronic
chr4:185558311(-) A-I      intronic
chr4:185558258(-) A-I      intronic
chr4:185558672(-) A-I      intronic
chr4:185560238(-) A-I      intronic
chr4:185560360(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CASP3
chr4:185570553(-) A-I exon 5'UTR    19478186
chr4:185558311(-) A-G intron -    22484847
chr4:185558672(-) A-G intron -    22484847
chr4:185563358(-) A-G intron -    22484847
chr4:185566794(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CASP3
chr4:185549472-185549473(-) m6A 3'UTR       24981863
chr4:185556524-185556525(-) m6A CDS       -
chr4:185556542-185556543(-) m6A CDS       -
chr4:185559556-185559557(-) m6A CDS       24981863
chr4:185559590-185559591(-) m6A CDS       24981863//27773535
chr4:185559599-185559600(-) m6A CDS       24981863//27773535
chr4:185565779-185565780(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Human milk     28688106
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Plasma     24937531
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
CASP3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7f-5p
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug sensitive
Artelastin 399488 Drug resistant
Salarin C 24867082 Drug resistant
Epilactose 128037 Drug resistant
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
organosulfur compound - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7f-5p
Formaldehyde 712 Drug interaction    RC00000304
Bisphenol A 6623 Drug interaction    RC00000311
Gemcitabine 60750 Drug interaction    RC00000315
Estradiol 5757 Drug interaction    RC00000310
Imatinib 5291 Drug interaction    RC00000309
Cholecalciferol 5280795 Drug interaction    RC00000319
Decitabine 451668 Drug interaction    RC00000318
Oleic acid 445639 Drug interaction    RC00000317
Docosahexaenoic acid 445580 Drug interaction    RC00000316
Letrozole 3902 Drug interaction    RC00000308
5-Fluorouracil 3385 Drug interaction    RC00000307
Doxorubicin 31703 Drug interaction    RC00000314
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000306
Verapamil 2520 Drug interaction    RC00000305
Arsenic trioxide 14888 Drug interaction    RC00000313
Hesperidin 10621 Drug interaction    RC00000312
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000320

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-5p
Interactor2: CASP3

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR
Support Database VIRmiRNA

References:


PMID 21565290 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

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