Detail Information

Basic Information:


  VIRBase ID:  

HHID00024028

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-186-5p:           TLR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-186-5p TLR3
miRBase
Accession/Entrez ID		 MIMAT0000456 7098
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD283//IIAE2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-186-5p
rs1205816145 chr1:71067693    G/T
rs1271550107 chr1:71067690    G/A
rs761777698 chr1:71067684    C/A
rs767418852 chr1:71067691    G/T
rs1445781653 chr1:71067699    T/C
rs749991806 chr1:71067698    C/G
rs749991806 chr1:71067698    C/T
rs905233879 chr1:71067701    T/C
rs959836009 chr1:71067695    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR3
chr4:187001863(+) A-I      intronic
chr4:187003336(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR3
chr4:186990367-186990368(+) m6A 5'UTR       24981863
chr4:186997778-186997779(+) m6A CDS       24981863
chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003978-187003979(+) m6A CDS//exon       24981863
chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863
chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863
chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863
chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004635-187004636(+) m6A CDS//exon       24981863
chr4:187004686-187004687(+) m6A CDS//exon       24981863
chr4:187004746-187004747(+) m6A CDS//exon       24981863
chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863
chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863
chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863
chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863
chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863
chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863
chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863
chr4:187005310-187005311(+) m6A CDS//exon       24981863
chr4:187005888-187005889(+) m6A CDS//exon       24981863
chr4:187005893-187005894(+) m6A CDS//exon       24981863
chr4:187005944-187005945(+) m6A CDS//exon       24981863
chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-186-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular Vesicle Plasma     28588009
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Neural progenitor cells     21363885
TLR3
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-186-5p
Iodine Green 9956454 Drug sensitive
Benzethonium chloride 8478 Drug sensitive
Vancide 26 79411 Drug sensitive
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive
Jacaranone 73307 Drug sensitive
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug sensitive
Laurolinium acetate 67354 Drug sensitive
Baccharinoid B4 6711263 Drug sensitive
Neocuproine 65237 Drug sensitive
Everolimus 6442177 Drug resistant
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
2,3-Dehydrosarcovagine D 54612860 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug sensitive
Cyclosporin A 5284373 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Epidoxoform 46877760 Drug sensitive
Oxyacanthine 442333 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Isobrucein A 441802 Drug sensitive
Glaucarubinone 441796 Drug sensitive
Fagaronine chloride 40304 Drug resistant
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Asimicinone 393461 Drug sensitive
Stereoisomer of NSC 674066-O 384359 Drug sensitive
(3R,5S)-Fluvastatin(1-) 37888681 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug sensitive
Jasplakinolide epoxide C 372550 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug sensitive
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive
3-Deazaneplanocin hydrochloride 358176 Drug sensitive
Dolastatin 11 354399 Drug sensitive
2-Isopropenyl-4,6-diphenoxy-1,3,5-triazine 340916 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
Tamoxifen 2733526 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
2-[4-(Methoxy)phenyltio]-3-phenyl-5,7-diamino quinoxaline 24203447 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Astraphloxin 12299852 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
Capri Blue 102162 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
[(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug resistant
(-)-furodysinin - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
2,3-dihydro-2,3-dihydroxy-brefeldin a - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
antineoplastic-615538 - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
sphinxolide e - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-186-5p
Formaldehyde 712 Drug interaction    RC00003221
Gemcitabine 60750 Drug interaction    RC00003229
Vincristine 5978 Drug interaction    RC00003225
Mitomycin 5746 Drug interaction    RC00003224
Eloxatine 5310940 Drug interaction    RC00003231
Carboplatinum 38904 Drug interaction    RC00003228
Paclitaxel 36314 Drug interaction    RC00003227
Doxorubicin 31703 Drug interaction    RC00003226
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003223
Verapamil 2520 Drug interaction    RC00003222
Ginsenoside Rh2 119307 Drug interaction    RC00003230
platinum-based doublet chemotherapy - Drug interaction    RC00003232
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003233

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-186-5p
Interactor2: TLR3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

Starting a new search, please wait ...