Basic Information
| RNALocate ID: | RLID:11001955 |
| RNA Symbol: | hsa-miR-186-5p |
| Localization: | Exosome |
RNA Information
| RNA Name: | hsa-miR-186-5p |
| RNA ID: | miRBase:MIMAT0000456 |
| RNA Category: | miRNA |
| Species: | Homo sapiens |
Localization Information
| PubMed ID: | 22211110 |
| Tissue/Cell Line: | Breast milk |
| Method: | Next-generation RNA sequencing |
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The expression profile of selected miRNAs in breast milk exosomes. Originally published in Int J Biol Sci. Zhou Q, et al, 2012. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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| Description: | Distribution and characterization of miRNAs in breast milk exosomes. (A) Distribution of pre-miRNAs. Out of 1,424 pre-miRNAs deposited in miRBase 17.0 (blue circle), 87 (6.11%) pre-miRNAs have been designated as immune-related pre-miRNAs based on annotation in the Pathway Central database (SABiosciences, MD, USA). Immune-related pre-miRNAs (59 of 452, 13.05%) are enriched in breast milk exosomes (red circle). χ2 test: Number of immune-related miRNAs and others detected in breast milk exosomes compared with the total entries in miRBase 17.0. (B) Top ten most highly expressed unique miRNAs. Plot of the unique miRNAs (starting from the miRNA with the highest counts, x-axis) versus their cumulative % of the total counts from 602 unique miRNAs detected in breast milk exosomes for each small RNA library. Values are means ± s.d. The dashed horizontal line at 62.3% represents the level of the top ten unique miRNAs and the % of individual miRNAs is marked by the gray line. (C-E) The expression profile of selected miRNAs in breast milk exosomes. (C) 59 immune-related pre-miRNAs; (D) miR-17-92 cluster and paralogous clusters, and (E) ten well-characterized tissue-specific pre-miRNAs. Data are collected from Figure 2. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:01001846 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:01001847 | Mitochondrion | Skeletal muscle myoblasts | 21637849 |
| RLID:01001848 | Mitochondrion | Cell line (HEK-293|HeLa) | 22984580 |
| RLID:01001849 | Nucleus | Neural progenitor cells | 21363885 |
| RLID:11001953 | Exosome | Primary dendritic cells|T cell line (J77) | 21505438 |
| RLID:11001954 | Exosome | Renal cancer cells | 21670082 |
| RLID:11001956 | Exosome | Brain tissue | 23382797 |
| RLID:11001957 | Exosome | Plasma | 23663360 |
| RLID:11001958 | Exosome | Human mast cell line (HMC-1) | 24009880 |
| RLID:11001959 | Extracellular Vesicle | Plasma | 28588009 |
| RLID:11001960 | Extracellular vesicle | HEK-293T cells | 22849433 |
| RLID:11001961 | Microvesicle | Plasma | 23077538 |
| RLID:11001962 | Microvesicle | Follicular fluid | 23666971 |
| RLID-D:11000101 | Exosome | Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue | |
| RLID-D:11000384 | Microvesicle | Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | hsa-miR-186-5p | Diffuse large b cell lymphoma | MNDR-E-MI-21154 |
| MNDR | hsa-miR-186-5p | Medulloblastoma | MNDR-E-MI-21155 |
| MNDR | hsa-miR-186-5p | Lymphoma | MNDR-E-MI-21156 |
| MNDR | hsa-miR-186-5p | Dermatomyositis | MNDR-E-MI-21157 |
| MNDR | hsa-miR-186-5p | Prostate cancer | MNDR-E-MI-21158 |
| MNDR | hsa-miR-186-5p | Gastric cancer | MNDR-E-MI-21159 |
| MNDR | hsa-miR-186-5p | Alzheimer disease | MNDR-E-MI-21160 |
| MNDR | hsa-miR-186-5p | Intracranial aneurysm | MNDR-E-MI-21161 |
| MNDR | hsa-miR-186-5p | Esophageal carcinoma | MNDR-E-MI-21162 |
| MNDR | hsa-miR-186-5p | Dysautonomia familial | MNDR-E-MI-21163 |
| MNDR | hsa-miR-186-5p | Polycystic ovary syndrome | MNDR-E-MI-21164 |
| MNDR | hsa-miR-186-5p | Leukemia | MNDR-E-MI-21165 |
| MNDR | hsa-miR-186-5p | Cardiovascular disease | MNDR-E-MI-21166 |
| MNDR | hsa-miR-186-5p | Focal segmental glomerulosclerosis | MNDR-E-MI-21167 |
| MNDR | hsa-miR-186-5p | Lung cancer | MNDR-E-MI-21168 |
| MNDR | hsa-miR-186-5p | Down syndrome | MNDR-E-MI-21169 |
| MNDR | hsa-miR-186-5p | Parkinson disease | MNDR-E-MI-21170 |
| MNDR | hsa-miR-186-5p | Breast cancer | MNDR-E-MI-21171 |
| MNDR | hsa-miR-186-5p | Pituitary neoplasms | MNDR-E-MI-21172 |
| MNDR | hsa-miR-186-5p | Pancreatic cancer | MNDR-E-MI-21173 |
| MNDR | hsa-miR-186-5p | Melanoma | MNDR-E-MI-21174 |
| MNDR | hsa-miR-186-5p | Rectum adenocarcinoma | MNDR-E-MI-21175 |
| MNDR | hsa-miR-186-5p | Colon cancer | MNDR-E-MI-21176 |
| MNDR | hsa-miR-186-5p | Colon adenocarcinoma | MNDR-E-MI-21177 |
| MNDR | hsa-miR-186-5p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-21178 |
| MNDR | hsa-miR-186-5p | Familial ovarian cancer | MNDR-E-MI-21179 |
| MNDR | hsa-miR-186-5p | Prostate adenocarcinoma | MNDR-E-MI-21180 |
| MNDR | hsa-miR-186-5p | Kidney cancer | MNDR-E-MI-21181 |
| MNDR | hsa-miR-186-5p | Carcinoma ductal breast | MNDR-E-MI-21182 |
| MNDR | hsa-miR-186-5p | Glioblastoma | MNDR-E-MI-21183 |
| MNDR | hsa-miR-186-5p | Glioma | MNDR-E-MI-21184 |
| MNDR | hsa-miR-186-5p | Chronic obstructive pulmonary disease | MNDR-E-MI-21185 |
| MNDR | hsa-miR-186-5p | Amyotrophic lateral sclerosis | MNDR-E-MI-21186 |
| MNDR | hsa-miR-186-5p | Osteosarcoma | MNDR-E-MI-21187 |
| MNDR | hsa-miR-186-5p | Inclusion body myositis | MNDR-E-MI-21188 |
| MNDR | hsa-miR-186-5p | Meningioma | MNDR-E-MI-21189 |
| MNDR | hsa-miR-186-5p | Uterine cancer | MNDR-E-MI-21190 |
| MNDR | hsa-miR-186-5p | Gastric adenocarcinoma | MNDR-E-MI-21191 |
| MNDR | hsa-miR-186-5p | Cervical squamous cell carcinoma | MNDR-E-MI-21192 |
| MNDR | hsa-miR-186-5p | Pituitary adenoma | MNDR-E-MI-21193 |
| MNDR | hsa-miR-186-5p | Lung squamous cell carcinoma | MNDR-E-MI-21194 |
| MNDR | hsa-miR-186-5p | Lung adenocarcinoma | MNDR-E-MI-21195 |
| MNDR | hsa-miR-186-5p | Thyroid carcinoma | MNDR-E-MI-21196 |
| MNDR | hsa-miR-186-5p | Pancreatic adenocarcinoma | MNDR-E-MI-21197 |
| MNDR | hsa-miR-186-5p | Kidney renal clear cell carcinoma | MNDR-E-MI-21198 |
| MNDR | hsa-miR-186-5p | Kidney renal papillary cell carcinoma | MNDR-E-MI-21199 |
| MNDR | hsa-miR-186-5p | Renal clear cell carcinoma | MNDR-E-MI-21200 |
| MNDR | hsa-miR-186-5p | Cholangiocarcinoma | MNDR-E-MI-21201 |
| MNDR | hsa-miR-186-5p | Esophageal cancer | MNDR-E-MI-21202 |
| MNDR | hsa-miR-186-5p | Head and neck squamous cell carcinoma | MNDR-E-MI-21203 |
| MNDR | hsa-miR-186-5p | Growth hormone-secreting pituitary adenoma | MNDR-E-MI-21204 |
| MNDR | hsa-miR-186-5p | Breast invasive carcinoma | MNDR-E-MI-21205 |
| MNDR | hsa-miR-186-5p | Hepatocellular carcinoma | MNDR-E-MI-21206 |
| MNDR | hsa-miR-186-5p | Familiar ovarian carcinoma | MNDR-E-MI-21207 |
| MNDR | hsa-miR-186-5p | B-cell lymphoma | MNDR-E-MI-21208 |
| MNDR | hsa-miR-186-5p | Rheumatoid arthritis | MNDR-E-MI-21209 |
| MNDR | hsa-miR-186-5p | Retinoblastoma | MNDR-E-MI-21210 |
| MNDR | hsa-miR-186-5p | Hodgkin lymphoma | MNDR-E-MI-21211 |
| MNDR | hsa-miR-186-5p | Tonsil cancer | MNDR-E-MI-21212 |
| MNDR | hsa-miR-186-5p | Neuromyelitis optica | MNDR-E-MI-21213 |
| MNDR | hsa-miR-186-5p | Skin cutaneous melanoma | MNDR-E-MI-21214 |
| MNDR | hsa-miR-186-5p | Skin melanoma | MNDR-E-MI-21215 |
| MNDR | hsa-miR-186-5p | Colorectal cancer | MNDR-E-MI-21216 |
| MNDR | hsa-miR-186-5p | Multiple myeloma | MNDR-E-MI-21217 |
| MNDR | hsa-miR-186-5p | Prostatic neoplasms | MNDR-E-MI-21218 |
| MNDR | hsa-miR-186-5p | Hypersomnolence idiopathic | MNDR-E-MI-21219 |
| MNDR | hsa-miR-186-5p | Cerebral hemorrhage traumatic | MNDR-E-MI-21220 |
| MNDR | hsa-miR-186-5p | Stroke lacunar | MNDR-E-MI-21221 |
| MNDR | hsa-miR-186-5p | Solid-pseudopapillary neoplasm of pancreas | MNDR-E-MI-21222 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | ABCB1 | Homo sapiens | RR00022776 |
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