Basic Information:

  VIRBase ID:  

HHID00023752

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-149-5p:  MIMAT0000450          IL6:  NM_001318095     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-149-5p	IL6
miRBase Accession/Entrez ID	MIMAT0000450	3569
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-149-5p	rs773885113 chr2:240456037    C/T rs901919526 chr2:240456023    C/T rs998903950 chr2:240456024    G/A rs998903950 chr2:240456024    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-149-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary ovarian tumor cells|Serum     18589210 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Endothelial cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-149-5p	Gemcitabine 60750 Drug interaction    RC00003170 Temozolomide 5394 Drug interaction    RC00003165 Goserelinacetate 47725 Drug interaction    RC00003169 Bortezomib 387447 Drug interaction    RC00003173 Paclitaxel 36314 Drug interaction    RC00003168 5-Fluorouracil 3385 Drug interaction    RC00003164 Doxorubicin 31703 Drug interaction    RC00003167 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003163 Tamoxifen 2733526 Drug interaction    RC00003174 Bicalutamide 2375 Drug interaction    RC00003162 Arsenic trioxide 14888 Drug interaction    RC00003166 Docetaxel 148124 Drug interaction    RC00003172 Methotrexate 126941 Drug interaction    RC00003171 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003175

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-149-5p	Cisplatin 5702198       29393390

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-149-5p
Interactor2: IL6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).