Basic Information:

  VIRBase ID:  

HHID00023522

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-210-5p:  MIMAT0026475          STAT5A:  NM_001288719     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-210-5p	STAT5A
miRBase Accession/Entrez ID	MIMAT0026475	6776
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MGF//STAT5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-210-5p	rs1307849834 chr11:568150    C/T rs1328893125 chr11:568155    T/A rs1339953548 chr11:568159    G/A rs1392659721 chr11:568157    C/T rs1393385015 chr11:568155    TGC/T rs1394548019 chr11:568152    G/C rs1484589425 chr11:568153    T/C rs758885854 chr11:568158    G/A rs764507105 chr11:568162    G/A rs764507105 chr11:568162    G/T rs887377650 chr11:568163    G/A rs1317060428 chr11:568166    G/A rs1373131153 chr11:568167    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STAT5A	chr17:40446076(+) A-I      intronic chr17:40446080(+) A-I      intronic chr17:40446204(+) A-I      intronic chr17:40446179(+) A-I      intronic chr17:40446175(+) A-I      intronic chr17:40446123(+) A-I      intronic chr17:40446980(+) A-I      intronic chr17:40446056(+) A-I      intronic chr17:40457060(+) A-I      intronic chr17:40446216(+) A-I      intronic chr17:40446073(+) A-I      intronic chr17:40446075(+) A-I      intronic chr17:40446057(+) A-I      intronic chr17:40446084(+) A-I      intronic chr17:40446078(+) A-I      intronic chr17:40446047(+) A-I      intronic chr17:40446026(+) A-I      intronic chr17:40445420(+) A-I      intronic chr17:40445356(+) A-I      intronic chr17:40445322(+) A-I      intronic chr17:40444603(+) A-I      intronic chr17:40444604(+) A-I      intronic chr17:40445303(+) A-I      intronic chr17:40445403(+) A-I      intronic chr17:40457138(+) A-I      intronic chr17:40444448(+) A-I      intronic chr17:40457038(+) A-I      intronic chr17:40457019(+) A-I      intronic chr17:40457018(+) A-I      intronic chr17:40455563(+) A-I      intronic chr17:40455549(+) A-I      intronic chr17:40454099(+) A-I      intronic chr17:40446242(+) A-I      intronic chr17:40446214(+) A-I      intronic chr17:40446213(+) A-I      intronic chr17:40446114(+) A-I      intronic chr17:40446087(+) A-I      intronic chr17:40457042(+) A-I      intronic chr17:40445406(+) A-I      intronic chr17:40445348(+) A-I      intronic chr17:40453621(+) A-I      intronic chr17:40454123(+) A-I      intronic chr17:40446964(+) A-I      intronic chr17:40453583(+) A-I      intronic chr17:40444486(+) A-I      intronic chr17:40446239(+) A-I      intronic chr17:40446240(+) A-I      intronic chr17:40454679(+) A-I      intronic chr17:40445340(+) A-I      intronic chr17:40455473(+) A-I      intronic chr17:40454081(+) A-I      intronic chr17:40446081(+) A-I      intronic chr17:40443710(+) A-I      intronic chr17:40445259(+) A-I      intronic chr17:40453636(+) A-I      intronic chr17:40445323(+) A-I      intronic chr17:40444476(+) A-I      intronic chr17:40445412(+) A-I      intronic chr17:40446113(+) A-I      intronic chr17:40445497(+) A-I      intronic chr17:40444553(+) A-I      intronic chr17:40445955(+) A-I      intronic chr17:40445254(+) A-I      intronic chr17:40453635(+) A-I      intronic chr17:40446995(+) A-I      intronic chr17:40446996(+) A-I      intronic chr17:40446224(+) A-I      intronic chr17:40455528(+) A-I      intronic chr17:40445978(+) A-I      intronic chr17:40453626(+) A-I      intronic chr17:40445458(+) A-I      intronic chr17:40453612(+) A-I      intronic chr17:40445362(+) A-I      intronic chr17:40445297(+) A-I      intronic chr17:40443150(+) A-I      intronic chr17:40454723(+) A-I      intronic chr17:40445352(+) A-I      intronic chr17:40446119(+) A-I      intronic chr17:40443473(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STAT5A	chr17:40453636(+) A-I intron -    22327324 chr17:40453636(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STAT5A	chr17:40439566-40439567(+) m6A 5'UTR       - chr17:40439619-40439620(+) m6A 5'UTR       - chr17:40439641-40439642(+) m6A 5'UTR       - chr17:40439996-40439997(+) m6A 5'UTR//intron       - chr17:40440012-40440013(+) m6A 5'UTR//intron       - chr17:40440157-40440158(+) m6A 5'UTR       - chr17:40440290-40440291(+) m6A 5'UTR       - chr17:40440301-40440302(+) m6A 5'UTR       - chr17:40440547-40440548(+) m6A 5'UTR//exon       - chr17:40441900-40441901(+) m6A 5'UTR//CDS//exon       - chr17:40441912-40441913(+) m6A 5'UTR//CDS//exon       - chr17:40452764-40452765(+) m6A CDS       - chr17:40452863-40452864(+) m6A CDS       - chr17:40453332-40453333(+) m6A CDS       - chr17:40453338-40453339(+) m6A CDS       - chr17:40453462-40453463(+) m6A CDS       - chr17:40456226-40456227(+) m6A exon//intron       - chr17:40461089-40461090(+) m6A CDS//exon       - chr17:40461444-40461445(+) m6A CDS//exon       - chr17:40461660-40461661(+) m6A 3'UTR//intron       - chr17:40462570-40462571(+) m6A CDS       25456834//24981863 chr17:40462599-40462600(+) m6A CDS       25456834//24981863 chr17:40462619-40462620(+) m6A CDS       25456834//24981863 chr17:40462716-40462717(+) m6A 3'UTR       - chr17:40463545-40463546(+) m6A 3'UTR       - chr17:40463559-40463560(+) m6A 3'UTR       - chr17:40463594-40463595(+) m6A 3'UTR       - chr17:40463600-40463601(+) m6A 3'UTR       - chr17:40463607-40463608(+) m6A 3'UTR       - chr17:40463620-40463621(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-210-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Plasma     19289371 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815 Nucleus Neural progenitor cells     21363885
	STAT5A	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-210-5p
Interactor2: STAT5A

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.