Basic Information:

  VIRBase ID:  

HHID00023492

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3065-5p:  MIMAT0015066          OTX1:  NR_130153     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3065-5p	OTX1
miRBase Accession/Entrez ID	MIMAT0015066	5013
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3065-5p	rs1489376916 chr17:81125899    T/A rs931624243 chr17:81125895    T/C rs1263458335 chr17:81125892    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OTX1	chr2:63278001-63278002(+) m6A 5'UTR//exon//intron       24981863 chr2:63278014-63278015(+) m6A 5'UTR//exon//intron       24981863 chr2:63278075-63278076(+) m6A exon//intron       24981863 chr2:63282648-63282649(+) m6A 3'UTR//CDS       24284625 chr2:63282692-63282693(+) m6A 3'UTR//CDS       24284625 chr2:63282864-63282865(+) m6A 3'UTR//CDS       - chr2:63283125-63283126(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr2:63283381-63283382(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr2:63283410-63283411(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr2:63283419-63283420(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr2:63283555-63283556(+) m6A 3'UTR       24284625//24209618//24981863 chr2:63283639-63283640(+) m6A 3'UTR       24284625//24209618//24981863 chr2:63283665-63283666(+) m6A 3'UTR       24284625//24209618//24981863 chr2:63283738-63283739(+) m6A 3'UTR       24284625//24209618//24981863 chr2:63283769-63283770(+) m6A 3'UTR       24284625//24209618//24981863 chr2:63283853-63283854(+) m6A 3'UTR       24284625//25456834//24981863 chr2:63283918-63283919(+) m6A 3'UTR       24284625//25456834//24981863 chr2:63283943-63283944(+) m6A 3'UTR       24284625//25456834//24981863 chr2:63284116-63284117(+) m6A 3'UTR       24284625//24981863 chr2:63284174-63284175(+) m6A 3'UTR       24284625//24981863 chr2:63284183-63284184(+) m6A 3'UTR       24284625//24981863 chr2:63284210-63284211(+) m6A 3'UTR       24284625//24981863 chr2:63284215-63284216(+) m6A 3'UTR       24284625//24981863 chr2:63284241-63284242(+) m6A 3'UTR       24284625//24981863 chr2:63284246-63284247(+) m6A 3'UTR       24284625//24981863 chr2:63284308-63284309(+) m6A 3'UTR       24981863 chr2:63284445-63284446(+) m6A 3'UTR       24284625 chr2:63284591-63284592(+) m6A 3'UTR       27773535 chr2:63284598-63284599(+) m6A 3'UTR       27773535 chr2:63284606-63284607(+) m6A 3'UTR       27773535 chr2:63284612-63284613(+) m6A 3'UTR       27773535 chr2:63284620-63284621(+) m6A 3'UTR       27773535 chr2:63284625-63284626(+) m6A 3'UTR       27773535 chr2:63284633-63284634(+) m6A 3'UTR       27773535 chr2:63284638-63284639(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3065-5p	Exosome Plasma     23663360 Exosome Serum     25349172 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	OTX1	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3065-5p
Interactor2: OTX1

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.