Basic Information:

  VIRBase ID:  

HHID00023405

  Virus:  

Zika virus (strain PRVABC59,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9584

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-142-5p:  MIMAT0000433          ITGAV:  NM_002210     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-142-5p	ITGAV
miRBase Accession/Entrez ID	MIMAT0000433	3685
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD51//MSK8//VNRA//VTNR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-142-5p	rs1240205037 chr17:58331289    G/A rs1441344858 chr17:58331294    C/G rs746452985 chr17:58331288    T/G rs867010562 chr17:58331300    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITGAV	chr2:187527238(+) A-I      intronic chr2:187527237(+) A-I      intronic chr2:187527222(+) A-I      intronic chr2:187527216(+) A-I      intronic chr2:187527206(+) A-I      intronic chr2:187527205(+) A-I      intronic chr2:187527195(+) A-I      intronic chr2:187527191(+) A-I      intronic chr2:187493603(+) A-I      intronic chr2:187493590(+) A-I      intronic chr2:187493324(+) A-I      intronic chr2:187493641(+) A-I      intronic chr2:187493638(+) A-I      intronic chr2:187493634(+) A-I      intronic chr2:187493626(+) A-I      intronic chr2:187493601(+) A-I      intronic chr2:187493585(+) A-I      intronic chr2:187493583(+) A-I      intronic chr2:187493581(+) A-I      intronic chr2:187493306(+) A-I      intronic chr2:187493305(+) A-I      intronic chr2:187493302(+) A-I      intronic chr2:187493294(+) A-I      intronic chr2:187493276(+) A-I      intronic chr2:187493275(+) A-I      intronic chr2:187493303(+) A-I      intronic chr2:187493301(+) A-I      intronic chr2:187493298(+) A-I      intronic chr2:187493291(+) A-I      intronic chr2:187508891(+) A-I      intronic chr2:187508750(+) A-I      intronic chr2:187513547(+) A-I      intronic chr2:187493567(+) A-I      intronic chr2:187493607(+) A-I      intronic chr2:187468800(+) A-I      intronic chr2:187508740(+) A-I      intronic chr2:187508745(+) A-I      intronic chr2:187513608(+) A-I      intronic chr2:187513553(+) A-I      intronic chr2:187513550(+) A-I      intronic chr2:187513549(+) A-I      intronic chr2:187493569(+) A-I      intronic chr2:187493565(+) A-I      intronic chr2:187493369(+) A-I      intronic chr2:187493368(+) A-I      intronic chr2:187455371(+) A-I      intronic chr2:187527493(+) A-I      intronic chr2:187527480(+) A-I      intronic chr2:187527462(+) A-I      intronic chr2:187527432(+) A-I      intronic chr2:187527426(+) A-I      intronic chr2:187527252(+) A-I      intronic chr2:187527251(+) A-I      intronic chr2:187527240(+) A-I      intronic chr2:187527239(+) A-I      intronic chr2:187508675(+) A-I      intronic chr2:187510517(+) A-I      intronic chr2:187510507(+) A-I      intronic chr2:187510456(+) A-I      intronic chr2:187510600(+) A-I      intronic chr2:187510440(+) A-I      intronic chr2:187508682(+) A-I      intronic chr2:187518895(+) A-I      intronic chr2:187518898(+) A-I      intronic chr2:187518901(+) A-I      intronic chr2:187518904(+) A-I      intronic chr2:187508871(+) A-I      intronic chr2:187496589(+) A-I      intronic chr2:187496572(+) A-I      intronic chr2:187476222(+) A-I      intronic chr2:187476216(+) A-I      intronic chr2:187467510(+) A-I      intronic chr2:187467356(+) A-I      intronic chr2:187508764(+) A-I      intronic chr2:187508788(+) A-I      intronic chr2:187509273(+) A-I      intronic chr2:187508810(+) A-I      intronic chr2:187517737(+) A-I      intronic chr2:187517685(+) A-I      intronic chr2:187517100(+) A-I      intronic chr2:187510627(+) A-I      intronic chr2:187510605(+) A-I      intronic chr2:187519005(+) A-I      intronic chr2:187510588(+) A-I      intronic chr2:187510578(+) A-I      intronic chr2:187510552(+) A-I      intronic chr2:187509253(+) A-I      intronic chr2:187509192(+) A-I      intronic chr2:187509198(+) A-I      intronic chr2:187510539(+) A-I      intronic chr2:187496592(+) A-I      intronic chr2:187466081(+) A-I      intronic chr2:187467525(+) A-I      intronic chr2:187510620(+) A-I      intronic chr2:187510624(+) A-I      intronic chr2:187468615(+) A-I      intronic chr2:187467350(+) A-I      intronic chr2:187508845(+) A-I      intronic chr2:187510649(+) A-I      intronic chr2:187465607(+) A-I      intronic chr2:187466067(+) A-I      intronic chr2:187509152(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITGAV	chr2:187493271(+) A-I intron -    21960545 chr2:187493272(+) A-I intron -    21960545 chr2:187493352(+) A-I intron -    21960545 chr2:187493355(+) A-I intron -    21960545 chr2:187493549(+) A-I intron -    21960545 chr2:187493572(+) A-I intron -    21960545 chr2:187493582(+) A-I intron -    21960545 chr2:187493588(+) A-I intron -    21960545 chr2:187493271(+) A-G intron -    22484847 chr2:187493272(+) A-G intron -    22484847 chr2:187493582(+) A-G intron -    22484847 chr2:187493588(+) A-G intron -    22484847 chr2:187467350(+) A-G intron -    22484847 chr2:187467351(+) A-G intron -    22484847 chr2:187468615(+) A-G intron -    22484847 chr2:187497804(+) A-T intron -    22484847 chr2:187493352(+) A-G intron -    22484847 chr2:187493549(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGAV	chr2:187454835-187454836(+) m6A 5'UTR       24209618//25456834//24981863 chr2:187455130-187455131(+) m6A CDS       24209618//22575960 chr2:187455171-187455172(+) m6A CDS       24209618//22575960 chr2:187521091-187521092(+) m6A CDS       26404942 chr2:187542083-187542084(+) m6A 3'UTR       26404942 chr2:187544655-187544656(+) m6A 3'UTR       26404942 chr2:187544676-187544677(+) m6A 3'UTR       26404942 chr2:187545386-187545387(+) m6A 3'UTR       27773535 chr2:187545496-187545497(+) m6A 3'UTR       27773535 chr2:187545555-187545556(+) m6A 3'UTR       27773535 chr2:187545609-187545610(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-142-5p	Endoplasmic reticulum membrane Cortical tissue     32451872 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Lymphoma tissue|Mast cells     - Microvesicle Plasma     19002258 Microvesicle Liver resident stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ITGAV	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-142-5p	Gemcitabine 60750 Drug interaction    RC00002827 Topotecan 60700 Drug interaction    RC00002826 Progesterone 5994 Drug interaction    RC00002823 D-Glucose 5793 Drug interaction    RC00002822 Dexamethasone 5743 Drug interaction    RC00002821 Eloxatine 5310940 Drug interaction    RC00002832 Sirolimus 5284616 Drug interaction    RC00002831 Paclitaxel 36314 Drug interaction    RC00002825 Doxorubicin 31703 Drug interaction    RC00002824 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002828 Benzene 241 Drug interaction    RC00002820 Gefitinib 123631 Drug interaction    RC00002830 Triptolide 107985 Drug interaction    RC00002829 Neomycin - Drug interaction    RC00002833

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-142-5p	Gemcitabine 60750       21347785 Topotecan 60700       19237188 Cisplatin 5702198       30639456 Doxorubicin 31703       30536312

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-142-5p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Nutlin-3       216345 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-142-5p
Interactor2: ITGAV

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR
Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	32902370	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	293T cells//A549 cells	Interactor2 expression	None
Description	Overexpression of miR-142-5p in ZIKV- infected A549 cells significantly attenuated ZIKV NS5 gene expression, while it markedly reduced IL6ST and ITGAV expressions at the mRNA level (Figure 6(C)),.