Basic Information
RNALocate ID: RLID:11001776
RNA Symbol: hsa-miR-142-5p
Localization: Exosome
RNA Information
RNA Name: hsa-miR-142-5p
RNA ID: miRBase:MIMAT0000433
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 27278097
Tissue/Cell Line: Bronchoalveolar lavage fluid|Pooled sera
Method: miRNA array|qRT-PCR

MiRNAs involved in endothelial activation miR-92a and inflammation miR-182, AMR miR-142-5p, and Th 17 activation miR-155 in exosomes derived from sera and BAL fluid from BOS LTxRs compared with stable LTxRs. (y axis: relative fold change; x axis: sample source).

Originally published in Am J Transplant. Gunasekaran M, et al, 2017. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: qRT-PCR demonstrated significant upregulation of miR-92a (p<0.013) and miR-182 (p<0.020) in AR LTxRs compared with stable LTxRs, and significant upregulation of miR-92a (p<0.041), miR-182 (p<0.012), miR-142-5p (p<0.015), and miR-155 (p<0.002) in BOS LTxRs compared with stable LTxRs. Similarly, exosomes derived from BAL fluid showed significant upregulation of miR-92a (p<0.014) and miR-182 (p<0.026) in AR LTxRs compared with stable LTxRs, and significant upregulation of miR-92a (p<0.024), miR-182 (p<0.026), miR-142-5p (p<0.026), and miR-155 (p<0.008) in BOS LTxRs compared with stable LTxRs (Figure 7). This shows that miRNAs involved in inflammation and endothelial activation were significantly increased in both AR and BOS LTxRs, and that the IL17 pathway was activated in BOS LTxRs.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001785 Endoplasmic reticulum membrane Cortical tissue 32451872
RLID:11001777 Exosome Primary dendritic cells|T cell line (J77) 21505438
RLID:11001778 Exosome Renal cancer cells 21670082
RLID:11001779 Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5) 21721029
RLID:11001780 Exosome Breast milk 22211110
RLID:11001781 Exosome Brain tissue 23382797
RLID:11001782 Exosome Plasma 23663360
RLID:11001783 Exosome Human mast cell line (HMC-1) 24009880
RLID:11001785 Microvesicle Liver resident stem cells 20668554
RLID:11001786 Microvesicle Plasma 23077538
RLID-D:11000083 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Lymphoma tissue|Mast cells
RLID-D:11000361 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-miR-142-5p Mantle cell lymphoma MNDR-E-MI-14022
MNDR hsa-miR-142-5p Splenic marginal zone lymphoma MNDR-E-MI-14023
MNDR hsa-miR-142-5p Multiple sclerosis chronic progressive MNDR-E-MI-14024
MNDR hsa-miR-142-5p Oral squamous cell carcinoma MNDR-E-MI-14025
MNDR hsa-miR-142-5p Medulloblastoma MNDR-E-MI-14026
MNDR hsa-miR-142-5p Malt lymphoma MNDR-E-MI-14027
MNDR hsa-miR-142-5p Uterine corpus endometrial carcinoma MNDR-E-MI-14028
MNDR hsa-miR-142-5p Lymphoma MNDR-E-MI-14029
MNDR hsa-miR-142-5p Lymphoma non-hodgkin MNDR-E-MI-14030
MNDR hsa-miR-142-5p Estrogen-receptor positive breast cancer MNDR-E-MI-14031
MNDR hsa-miR-142-5p Estrogen-receptor negative breast cancer MNDR-E-MI-14032
MNDR hsa-miR-142-5p Progesterone-receptor positive breast cancer MNDR-E-MI-14033
MNDR hsa-miR-142-5p Progesterone-receptor negative breast cancer MNDR-E-MI-14034
MNDR hsa-miR-142-5p Her2-receptor positive breast cancer MNDR-E-MI-14035
MNDR hsa-miR-142-5p Breast cancer luminal MNDR-E-MI-14036
MNDR hsa-miR-142-5p Lupus nephritis MNDR-E-MI-14037
MNDR hsa-miR-142-5p Dermatomyositis MNDR-E-MI-14038
MNDR hsa-miR-142-5p Prostate cancer MNDR-E-MI-14039
MNDR hsa-miR-142-5p Hirschsprung disease MNDR-E-MI-14040
MNDR hsa-miR-142-5p Gastric lymphoma MNDR-E-MI-14041
MNDR hsa-miR-142-5p Alzheimer disease MNDR-E-MI-14042
MNDR hsa-miR-142-5p Intracranial aneurysm MNDR-E-MI-14043
MNDR hsa-miR-142-5p Esophageal carcinoma MNDR-E-MI-14044
MNDR hsa-miR-142-5p Head and neck cancer MNDR-E-MI-14045
MNDR hsa-miR-142-5p Malaria MNDR-E-MI-14046
MNDR hsa-miR-142-5p Leukemia MNDR-E-MI-14047
MNDR hsa-miR-142-5p Huntington disease MNDR-E-MI-14048
MNDR hsa-miR-142-5p Chorea MNDR-E-MI-14049
MNDR hsa-miR-142-5p Cardiovascular disease MNDR-E-MI-14050
MNDR hsa-miR-142-5p Lung cancer MNDR-E-MI-14051
MNDR hsa-miR-142-5p Parkinson disease MNDR-E-MI-14052
MNDR hsa-miR-142-5p Machado-joseph disease MNDR-E-MI-14053
MNDR hsa-miR-142-5p Basal-like breast cancer MNDR-E-MI-14054
MNDR hsa-miR-142-5p Pancreatic cancer MNDR-E-MI-14055
MNDR hsa-miR-142-5p Melanoma MNDR-E-MI-14056
MNDR hsa-miR-142-5p Rectum adenocarcinoma MNDR-E-MI-14057
MNDR hsa-miR-142-5p Nephroblastoma MNDR-E-MI-14058
MNDR hsa-miR-142-5p Colon cancer MNDR-E-MI-14059
MNDR hsa-miR-142-5p Colon adenocarcinoma MNDR-E-MI-14060
MNDR hsa-miR-142-5p Relapsing-remitting multiple sclerosis MNDR-E-MI-14061
MNDR hsa-miR-142-5p Familial ovarian cancer MNDR-E-MI-14062
MNDR hsa-miR-142-5p Carcinoma ductal breast MNDR-E-MI-14063
MNDR hsa-miR-142-5p Glioblastoma MNDR-E-MI-14064
MNDR hsa-miR-142-5p Malignant glioma MNDR-E-MI-14065
MNDR hsa-miR-142-5p Amyotrophic lateral sclerosis MNDR-E-MI-14066
MNDR hsa-miR-142-5p Osteosarcoma MNDR-E-MI-14067
MNDR hsa-miR-142-5p Inclusion body myositis MNDR-E-MI-14068
MNDR hsa-miR-142-5p Breast carcinoma MNDR-E-MI-14069
MNDR hsa-miR-142-5p Pancreatic ductal adenocarcinoma MNDR-E-MI-14070
MNDR hsa-miR-142-5p Meningioma MNDR-E-MI-14071
MNDR hsa-miR-142-5p Uterine cancer MNDR-E-MI-14072
MNDR hsa-miR-142-5p Gastric adenocarcinoma MNDR-E-MI-14073
MNDR hsa-miR-142-5p Cervical squamous cell carcinoma MNDR-E-MI-14074
MNDR hsa-miR-142-5p Lung squamous cell carcinoma MNDR-E-MI-14075
MNDR hsa-miR-142-5p Non-small cell lung cancer MNDR-E-MI-14076
MNDR hsa-miR-142-5p Lung adenocarcinoma MNDR-E-MI-14077
MNDR hsa-miR-142-5p Adrenocortical carcinoma MNDR-E-MI-14078
MNDR hsa-miR-142-5p Thyroid carcinoma MNDR-E-MI-14079
MNDR hsa-miR-142-5p Pancreatic adenocarcinoma MNDR-E-MI-14080
MNDR hsa-miR-142-5p Myasthenia gravis autoimmune experimental MNDR-E-MI-14081
MNDR hsa-miR-142-5p Carcinoma renal cell MNDR-E-MI-14082
MNDR hsa-miR-142-5p Kidney renal papillary cell carcinoma MNDR-E-MI-14083
MNDR hsa-miR-142-5p Clear cell renal cell cancer MNDR-E-MI-14084
MNDR hsa-miR-142-5p Cholangiocarcinoma MNDR-E-MI-14085
MNDR hsa-miR-142-5p Esophageal cancer MNDR-E-MI-14086
MNDR hsa-miR-142-5p Lung small cell carcinoma MNDR-E-MI-14087
MNDR hsa-miR-142-5p Testicular germ cell cancer MNDR-E-MI-14088
MNDR hsa-miR-142-5p Kidney diseases MNDR-E-MI-14089
MNDR hsa-miR-142-5p Breast invasive carcinoma MNDR-E-MI-14090
MNDR hsa-miR-142-5p Hepatocellular carcinoma MNDR-E-MI-14091
MNDR hsa-miR-142-5p Familiar ovarian carcinoma MNDR-E-MI-14092
MNDR hsa-miR-142-5p B-cell lymphoma MNDR-E-MI-14093
MNDR hsa-miR-142-5p Rheumatoid arthritis MNDR-E-MI-14094
MNDR hsa-miR-142-5p T-cell leukemia MNDR-E-MI-14095
MNDR hsa-miR-142-5p Retinoblastoma MNDR-E-MI-14096
MNDR hsa-miR-142-5p Barrett's adenocarcinoma MNDR-E-MI-14097
MNDR hsa-miR-142-5p Chronic fatigue syndrome MNDR-E-MI-14098
MNDR hsa-miR-142-5p Hodgkin lymphoma MNDR-E-MI-14099
MNDR hsa-miR-142-5p Ulcerative colitis MNDR-E-MI-14100
MNDR hsa-miR-142-5p Burkitt lymphoma MNDR-E-MI-14101
MNDR hsa-miR-142-5p Dementia vascular MNDR-E-MI-14102
MNDR hsa-miR-142-5p Tonsil cancer MNDR-E-MI-14103
MNDR hsa-miR-142-5p Neuromyelitis optica MNDR-E-MI-14104
MNDR hsa-miR-142-5p Skin cutaneous melanoma MNDR-E-MI-14105
MNDR hsa-miR-142-5p Skin melanoma MNDR-E-MI-14106
MNDR hsa-miR-142-5p Acute myeloid leukemia MNDR-E-MI-14107
MNDR hsa-miR-142-5p Colorectal cancer MNDR-E-MI-14108
MNDR hsa-miR-142-5p Nasopharynx carcinoma MNDR-E-MI-14109
MNDR hsa-miR-142-5p Multiple myeloma MNDR-E-MI-14110
MNDR hsa-miR-142-5p Fever MNDR-E-MI-14111
MNDR hsa-miR-142-5p Cardiac hypertrophy MNDR-E-MI-14112
MNDR hsa-miR-142-5p Nasopharyngeal cancer MNDR-E-MI-14113
MNDR hsa-miR-142-5p Aids dementia complex MNDR-E-MI-14114
MNDR hsa-miR-142-5p Stroke lacunar MNDR-E-MI-14115
MNDR hsa-miR-142-5p Barrett's carcinogenesis MNDR-E-MI-14116
MNDR hsa-miR-142-5p Breast cancer her3+ negative MNDR-E-MI-14117
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter AGER Homo sapiens RR00054545
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