Detail Information

Basic Information:


  VIRBase ID:  

HHID00023404

  Virus:  

Zika virus (strain PRVABC59,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9584

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-142-5p:           IL6ST:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-142-5p IL6ST
miRBase
Accession/Entrez ID		 MIMAT0000433 3572
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD130//CDW130//GP130//HIES4//IL-6RB//sGP130

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-142-5p
rs1240205037 chr17:58331289    G/A
rs1441344858 chr17:58331294    C/G
rs746452985 chr17:58331288    T/G
rs867010562 chr17:58331300    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6ST
chr5:55256638(-) A-I      intronic
chr5:55249408(-) A-I      intronic
chr5:55249478(-) A-I      intronic
chr5:55281259(-) A-I      intronic
chr5:55281245(-) A-I      intronic
chr5:55257423(-) A-I      intronic
chr5:55241678(-) A-I      intronic
chr5:55256634(-) A-I      intronic
chr5:55281233(-) A-I      intronic
chr5:55241607(-) A-I      intronic
chr5:55281099(-) A-I      intronic
chr5:55279080(-) A-I      intronic
chr5:55278966(-) A-I      intronic
chr5:55276830(-) A-I      intronic
chr5:55275055(-) A-I      intronic
chr5:55275016(-) A-I      intronic
chr5:55275003(-) A-I      intronic
chr5:55270935(-) A-I      intronic
chr5:55251249(-) A-I      intronic
chr5:55249481(-) A-I      intronic
chr5:55248791(-) A-I      intronic
chr5:55248751(-) A-I      intronic
chr5:55248723(-) A-I      intronic
chr5:55268829(-) A-I      intronic
chr5:55251163(-) A-I      intronic
chr5:55268616(-) A-I      intronic
chr5:55248807(-) A-I      intronic
chr5:55242910(-) A-I      intronic
chr5:55242900(-) A-I      intronic
chr5:55253475(-) A-I      intronic
chr5:55242892(-) A-I      intronic
chr5:55268824(-) A-I      intronic
chr5:55241564(-) A-I      intronic
chr5:55268278(-) A-I      intronic
chr5:55263794(-) A-I      intronic
chr5:55263780(-) A-I      intronic
chr5:55263761(-) A-I      intronic
chr5:55257474(-) A-I      intronic
chr5:55241655(-) A-I      intronic
chr5:55241541(-) A-I      intronic
chr5:55258677(-) A-I      intronic
chr5:55257504(-) A-I      intronic
chr5:55257503(-) A-I      intronic
chr5:55239819(-) A-I      intronic
chr5:55241650(-) A-I      intronic
chr5:55256715(-) A-I      intronic
chr5:55241627(-) A-I      intronic
chr5:55241600(-) A-I      intronic
chr5:55241617(-) A-I      intronic
chr5:55249691(-) A-I      intronic
chr5:55249486(-) A-I      intronic
chr5:55257403(-) A-I      intronic
chr5:55249409(-) A-I      intronic
chr5:55257360(-) A-I      intronic
chr5:55256732(-) A-I      intronic
chr5:55256731(-) A-I      intronic
chr5:55253511(-) A-I      intronic
chr5:55257467(-) A-I      intronic
chr5:55249366(-) A-I      intronic
chr5:55248826(-) A-I      intronic
chr5:55263784(-) A-I      intronic
chr5:55239905(-) A-I      intronic
chr5:55249388(-) A-I      intronic
chr5:55258866(-) A-I      intronic
chr5:55275015(-) A-I      intronic
chr5:55257326(-) A-I      intronic
chr5:55276807(-) A-I      intronic
chr5:55249314(-) A-I      intronic
chr5:55263788(-) A-I      intronic
chr5:55242501(-) A-I      intronic
chr5:55249677(-) A-I      intronic
chr5:55268576(-) A-I      intronic
chr5:55249661(-) A-I      intronic
chr5:55249315(-) A-I      intronic
chr5:55251161(-) A-I      intronic
chr5:55241648(-) A-I      intronic
chr5:55248687(-) A-I      intronic
chr5:55281175(-) A-I      intronic
chr5:55249446(-) A-I      intronic
chr5:55254523(-) A-I      intronic
chr5:55268159(-) A-I      intronic
chr5:55252829(-) A-I      intronic
chr5:55268667(-) A-I      intronic
chr5:55241546(-) A-I      intronic
chr5:55239784(-) A-I      intronic
chr5:55249364(-) A-I      intronic
chr5:55249387(-) A-I      intronic
chr5:55267482(-) A-I      intronic
chr5:55256541(-) A-I      intronic
chr5:55241653(-) A-I      intronic
chr5:55248660(-) A-I      intronic
chr5:55242964(-) A-I      intronic
chr5:55273194(-) A-I      intronic
chr5:55257517(-) A-I      intronic
chr5:55281087(-) A-I      intronic
chr5:55256622(-) A-I      intronic
chr5:55253970(-) A-I      intronic
chr5:55241750(-) A-I      intronic
chr5:55249573(-) A-I      intronic
chr5:55263654(-) A-I      intronic
chr5:55251153(-) A-I      intronic
chr5:55268151(-) A-I      intronic
chr5:55249746(-) A-I      intronic
chr5:55249280(-) A-I      intronic
chr5:55254493(-) A-I      intronic
chr5:55241659(-) A-I      intronic
chr5:55242916(-) A-I      intronic
chr5:55276757(-) A-I      intronic
chr5:55239873(-) A-I      intronic
chr5:55245069(-) A-I      intronic
chr5:55257542(-) A-I      intronic
chr5:55249495(-) A-I      intronic
chr5:55276849(-) A-I      intronic
chr5:55270294(-) A-I      intronic
chr5:55249651(-) A-I      intronic
chr5:55239823(-) A-I      intronic
chr5:55281158(-) A-I      intronic
chr5:55270507(-) A-I      intronic
chr5:55249784(-) A-I      intronic
chr5:55249693(-) A-I      intronic
chr5:55273570(-) A-I      intronic
chr5:55273572(-) A-I      intronic
chr5:55242609(-) A-I      intronic
chr5:55242799(-) A-I      intronic
chr5:55241706(-) A-I      intronic
chr5:55241658(-) A-I      intronic
chr5:55257547(-) A-I      intronic
chr5:55277286(-) A-I      intronic
chr5:55241662(-) A-I      intronic
chr5:55256635(-) A-I      intronic
chr5:55249779(-) A-I      intronic
chr5:55281084(-) A-I      intronic
chr5:55241711(-) A-I      intronic
chr5:55248780(-) A-I      intronic
chr5:55257356(-) A-I      intronic
chr5:55242975(-) A-I      intronic
chr5:55257320(-) A-I      intronic
chr5:55249572(-) A-I      intronic
chr5:55249385(-) A-I      intronic
chr5:55241657(-) A-I      intronic
chr5:55283802(-) A-I      intronic
chr5:55249739(-) A-I      intronic
chr5:55256869(-) A-I      intronic
chr5:55278930(-) A-I      intronic
chr5:55248806(-) A-I      intronic
chr5:55249355(-) A-I      intronic
chr5:55281177(-) A-I      intronic
chr5:55270942(-) A-I      intronic
chr5:55281118(-) A-I      intronic
chr5:55254036(-) A-I      intronic
chr5:55249378(-) A-I      intronic
chr5:55249323(-) A-I      intronic
chr5:55270609(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IL6ST
chr5:55249739(-) A-I intron -    21960545   //22327324
chr5:55253477(-) A-I intron -    22327324
chr5:55249733(-) A-I intron -    21960545
chr5:55249784(-) A-I intron -    21960545
chr5:55254804(-) A-I intron -    21960545
chr5:55270848(-) A-I intron -    21960545
chr5:55253615(-) A-G intron -    22484847
chr5:55239806(-) A-G intron -    22484847
chr5:55246569(-) T-C intron -    22484847
chr5:55248806(-) A-G intron -    22484847
chr5:55249314(-) A-G intron -    22484847
chr5:55249315(-) A-G intron -    22484847
chr5:55249323(-) A-G intron -    22484847
chr5:55249355(-) A-G intron -    22484847
chr5:55249356(-) A-G intron -    22484847
chr5:55249378(-) A-G intron -    22484847
chr5:55249382(-) A-G intron -    22484847
chr5:55249387(-) A-G intron -    22484847
chr5:55249451(-) A-G intron -    22484847
chr5:55249495(-) A-G intron -    22484847
chr5:55249573(-) A-G intron -    22484847
chr5:55249599(-) A-G intron -    22484847
chr5:55249661(-) A-G intron -    22484847
chr5:55249667(-) A-G intron -    22484847
chr5:55249675(-) A-G intron -    22484847
chr5:55249677(-) A-G intron -    22484847
chr5:55249693(-) A-G intron -    22484847
chr5:55249739(-) A-G intron -    22484847
chr5:55249784(-) A-G intron -    22484847
chr5:55254523(-) A-G intron -    22484847
chr5:55256582(-) A-G intron -    22484847
chr5:55256704(-) A-G intron -    22484847
chr5:55256861(-) C-T intron -    22484847
chr5:55256869(-) A-G intron -    22484847
chr5:55257356(-) A-G intron -    22484847
chr5:55257394(-) A-G intron -    22484847
chr5:55257547(-) A-G intron -    22484847
chr5:55262896(-) G-A intron -    22484847
chr5:55268151(-) A-G intron -    22484847
chr5:55270306(-) A-G intron -    22484847
chr5:55270507(-) A-G intron -    22484847
chr5:55270848(-) A-G intron -    22484847
chr5:55270942(-) A-G intron -    22484847
chr5:55273194(-) A-G intron -    22484847
chr5:55273570(-) A-G intron -    22484847
chr5:55273572(-) A-G intron -    22484847
chr5:55275015(-) A-G intron -    22484847
chr5:55276757(-) A-G intron -    22484847
chr5:55277286(-) A-G intron -    22484847
chr5:55281262(-) A-G intron -    22484847
chr5:55253477(-) A-G intron -    22484847
chr5:55253535(-) A-G intron -    22484847
chr5:55254780(-) A-G intron -    22484847
chr5:55254804(-) A-G intron -    22484847
chr5:55254841(-) A-G intron -    22484847
chr5:55254850(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6ST
chr5:55231354-55231355(-) m6A 3'UTR       27773535
chr5:55231396-55231397(-) m6A 3'UTR       24981863//27773535
chr5:55231462-55231463(-) m6A 3'UTR       27773535
chr5:55231479-55231480(-) m6A 3'UTR       27773535
chr5:55234704-55234705(-) m6A 3'UTR       24981863
chr5:55234742-55234743(-) m6A 3'UTR       24981863
chr5:55234771-55234772(-) m6A 3'UTR       24981863
chr5:55234823-55234824(-) m6A 3'UTR       26404942
chr5:55235756-55235757(-) m6A 3'UTR       27773535
chr5:55235761-55235762(-) m6A 3'UTR       27773535
chr5:55235766-55235767(-) m6A 3'UTR       27773535
chr5:55235790-55235791(-) m6A 3'UTR       27773535
chr5:55235909-55235910(-) m6A 3'UTR       27773535
chr5:55235932-55235933(-) m6A 3'UTR       27773535
chr5:55236036-55236037(-) m6A 3'UTR       27773535
chr5:55236065-55236066(-) m6A 3'UTR       27773535
chr5:55236129-55236130(-) m6A 3'UTR       27773535
chr5:55236472-55236473(-) m6A 3'UTR       26404942//27773535
chr5:55236503-55236504(-) m6A 3'UTR       26404942//27773535
chr5:55236593-55236594(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236617-55236618(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236644-55236645(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236693-55236694(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236710-55236711(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236776-55236777(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236786-55236787(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236905-55236906(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55236941-55236942(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55236998-55236999(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55237017-55237018(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55237119-55237120(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:55237125-55237126(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:55237213-55237214(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr5:55237218-55237219(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr5:55237362-55237363(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr5:55237411-55237412(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr5:55237497-55237498(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr5:55237531-55237532(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr5:55238569-55238570(-) m6A 3'UTR//CDS//exon       27773535
chr5:55243323-55243324(-) m6A 3'UTR//CDS//exon//intron       27773535
chr5:55244757-55244758(-) m6A exon//intron       27773535
chr5:55251961-55251962(-) m6A 3'UTR//CDS//exon//intron       26404942
chr5:55256332-55256333(-) m6A CDS//intron       26404942
chr5:55259205-55259206(-) m6A CDS//intron       26404942
chr5:55259259-55259260(-) m6A CDS//intron       26404942
chr5:55278598-55278599(-) m6A 5'UTR//exon//intron       27773536
chr5:55278634-55278635(-) m6A 5'UTR//exon//intron       27773536//22575960
chr5:55290711-55290712(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-142-5p
Endoplasmic reticulum membrane Cortical tissue     32451872
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Lymphoma tissue|Mast cells     -
Microvesicle Plasma     19002258
Microvesicle Liver resident stem cells     20668554
Microvesicle Plasma     23077538
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
IL6ST
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-142-5p
Gemcitabine 60750 Drug interaction    RC00002827
Topotecan 60700 Drug interaction    RC00002826
Progesterone 5994 Drug interaction    RC00002823
D-Glucose 5793 Drug interaction    RC00002822
Dexamethasone 5743 Drug interaction    RC00002821
Eloxatine 5310940 Drug interaction    RC00002832
Sirolimus 5284616 Drug interaction    RC00002831
Paclitaxel 36314 Drug interaction    RC00002825
Doxorubicin 31703 Drug interaction    RC00002824
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002828
Benzene 241 Drug interaction    RC00002820
Gefitinib 123631 Drug interaction    RC00002830
Triptolide 107985 Drug interaction    RC00002829
Neomycin - Drug interaction    RC00002833
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-142-5p
Gemcitabine 60750       21347785
Topotecan 60700       19237188
Cisplatin 5702198       30639456
Doxorubicin 31703       30536312
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-142-5p
Panobinostat       6918837
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Nutlin-3       216345
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-142-5p
Interactor2: IL6ST

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR
Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 32902370 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line 293T cells//A549 cells Interactor2 expression None
Description Overexpression of miR-142-5p in ZIKV- infected A549 cells significantly attenuated ZIKV NS5 gene expression, while it markedly reduced IL6ST and ITGAV expressions at the mRNA level (Figure 6(C)),.

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