Basic Information:

  VIRBase ID:  

HHID00020675

  Virus:  

Japanese encephalitis virus (P3 strain)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-27a-3p:  MIMAT0000537          Map2k3:  NR_157293     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-27a-3p	Map2k3
miRBase Accession/Entrez ID	MIMAT0000537	26397
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AW212142//MAPKK 3//MEK3//MKK3//MKK3b//Prkm//Prkmk3

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Map2k3	chr11:60932090-60932091(+) m6A 5'UTR//exon       25412662//24981863//25569111 chr11:60932264-60932265(+) m6A CDS//exon       25412662//25569111 chr11:60941900-60941901(+) m6A CDS//exon       25412662//25569111 chr11:60941979-60941980(+) m6A exon//intron       25412662//25569111 chr11:60942315-60942316(+) m6A CDS//exon       25683224//25412662//24981863 chr11:60942321-60942322(+) m6A CDS//exon       25683224//25412662//24981863 chr11:60942329-60942330(+) m6A CDS//exon       25683224//25412662//24981863 chr11:60942348-60942349(+) m6A CDS//exon       25683224//25412662//24981863//25569111 chr11:60942368-60942369(+) m6A exon//intron       25683224//25412662//24981863//25569111 chr11:60943505-60943506(+) m6A CDS//exon       25683224//25412662 chr11:60943535-60943536(+) m6A CDS//exon       25683224//25412662 chr11:60943541-60943542(+) m6A CDS//exon       25683224//25412662 chr11:60944695-60944696(+) m6A CDS//exon       25412662 chr11:60944737-60944738(+) m6A CDS//exon       25412662 chr11:60944755-60944756(+) m6A CDS//exon       25412662 chr11:60951168-60951169(+) m6A 3'UTR//CDS//exon       24981863 chr11:60951765-60951766(+) m6A 3'UTR//CDS//exon       24981863//25569111 chr11:60951790-60951791(+) m6A 3'UTR//CDS//exon       24981863//25569111 chr11:60951799-60951800(+) m6A 3'UTR//CDS//exon       24981863//25569111 chr11:60951849-60951850(+) m6A 3'UTR       24981863//25569111 chr11:60951860-60951861(+) m6A 3'UTR       24981863//25569111 chr11:60952009-60952010(+) m6A 3'UTR       24981863//25569111 chr11:60952014-60952015(+) m6A 3'UTR       24981863//25569111 chr11:60952174-60952175(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr11:60952250-60952251(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr11:60952278-60952279(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr11:60952307-60952308(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr11:60952334-60952335(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr11:60952402-60952403(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr11:60952417-60952418(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr11:60952463-60952464(+) m6A 3'UTR       25456834//24981863//25569111//22608085//22575960 chr11:60952576-60952577(+) m6A 3'UTR       25683224//25456834//24981863//25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-27a-3p	Exosome Mouse metastatic mammary carcinoma cells (4T1)|Non-tumorigenic mouse mammary epithelial cells (NMuMG)     25446899 Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Nucleus Liver cells     21862971

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-27a-3p
Interactor2: Map2k3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32552669	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Mice brain tissues	Interactor2 expression	None
Description	The circRNA-miRNA-mRNA ceRNA network.In total, we detected 569 negatively regulated miRNA-circRNA pairs and 2719 negatively regulated miRNA-mRNA pairs (Additional file 6: Table S5).