Basic Information
| RNALocate ID: | RLID:11002123 |
| RNA Symbol: | mmu-miR-27a-3p |
| Localization: | Exosome |
RNA Information
| RNA Name: | mmu-miR-27a |
| RNA ID: | miRBase:MIMAT0000537 |
| RNA Category: | miRNA |
| Species: | Mus musculus |
Localization Information
| PubMed ID: | 22031862 |
| Tissue/Cell Line: | B6 BMDCs |
| Method: | Microarray |
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Originally published in Blood. Montecalvo A, et al, 2012. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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| Description: | miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:01001906 | Mitochondrion | Heart tissue (subsarcolemmal and interfibrillar) | 26377859 |
| RLID:01001907 | Nucleus | Liver cells | 21862971 |
| RLID:11002121 | Exosome | Mouse metastatic mammary carcinoma cells (4T1)|Non-tumorigenic mouse mammary epithelial cells (NMuMG) | 25446899 |
| RLID:11002122 | Exosome | Serum | 28160157 |
| RLID:11002124 | Exosome | Mouse hypothalamic neuronal cell line (GT1-7) | 22965126 |
| RLID:11002125 | Exosome | Bone marrow-derived macrophages | 25159140 |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | mmu-miR-27a-3p | Multiple sclerosis chronic progressive | MNDR-E-MI-77610 |
| MNDR | mmu-miR-27a-3p | Medulloblastoma | MNDR-E-MI-77611 |
| MNDR | mmu-miR-27a-3p | Congenital myopathy | MNDR-E-MI-77612 |
| MNDR | mmu-miR-27a-3p | Alzheimer disease | MNDR-E-MI-77613 |
| MNDR | mmu-miR-27a-3p | Osteoporosis | MNDR-E-MI-77614 |
| MNDR | mmu-miR-27a-3p | Myotonic dystrophy | MNDR-E-MI-77615 |
| MNDR | mmu-miR-27a-3p | Rett syndrome | MNDR-E-MI-77616 |
| MNDR | mmu-miR-27a-3p | Neurogenic bladder | MNDR-E-MI-77617 |
| MNDR | mmu-miR-27a-3p | Cerebral malaria | MNDR-E-MI-77618 |
| MNDR | mmu-miR-27a-3p | Thyroid cancer | MNDR-E-MI-77619 |
| MNDR | mmu-miR-27a-3p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-77620 |
| MNDR | mmu-miR-27a-3p | Bronchiolitis obliterans | MNDR-E-MI-77621 |
| MNDR | mmu-miR-27a-3p | Amyotrophic lateral sclerosis | MNDR-E-MI-77622 |
| MNDR | mmu-miR-27a-3p | Osteosarcoma | MNDR-E-MI-77623 |
| MNDR | mmu-miR-27a-3p | Acute disseminated encephalomyelitis | MNDR-E-MI-77624 |
| MNDR | mmu-miR-27a-3p | Encephalomyelitis | MNDR-E-MI-77625 |
| MNDR | mmu-miR-27a-3p | Colorectal cancer | MNDR-E-MI-77626 |
| MNDR | mmu-miR-27a-3p | Encephalomyelitis venezuelan equine | MNDR-E-MI-77627 |
| MNDR | mmu-miR-27a-3p | Diabetic neuropathy | MNDR-E-MI-77628 |
| MNDR | mmu-miR-27a-3p | Galactosemias | MNDR-E-MI-77629 |
| MNDR | mmu-miR-27a-3p | Dwarfism pituitary | MNDR-E-MI-77630 |
| MNDR | mmu-miR-27a-3p | Encephalomyelitis autoimmune experimental | MNDR-E-MI-77631 |
| MNDR | mmu-miR-27a-3p | Hyperalgesia | MNDR-E-MI-77632 |
| MNDR | mmu-miR-27a-3p | Epilepsia partialis continua | MNDR-E-MI-77633 |
| MNDR | mmu-miR-27a-3p | Sepsis | MNDR-E-MI-77634 |
| MNDR | mmu-miR-27a-3p | Brain injury chronic | MNDR-E-MI-77635 |
| MNDR | mmu-miR-27a-3p | Peripheral nerve injuries | MNDR-E-MI-77636 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | Bbc3 | Mus musculus | RR00237949 |
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