Basic Information:

  VIRBase ID:  

HHID00020666

  Virus:  

Japanese encephalitis virus (P3 strain)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-27a-3p:  MIMAT0000537          Il6:  NM_001314054     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-27a-3p	Il6
miRBase Accession/Entrez ID	MIMAT0000537	16193
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Il//Il-6

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Il6	chr5:30014859-30014860(+) m6A CDS       25412662 chr5:30014883-30014884(+) m6A CDS       25412662 chr5:30014893-30014894(+) m6A CDS       25412662 chr5:30014930-30014931(+) m6A CDS       25412662 chr5:30019470-30019471(+) m6A 3'UTR//CDS       24981863 chr5:30019476-30019477(+) m6A 3'UTR//CDS       24981863 chr5:30019542-30019543(+) m6A 3'UTR//CDS       24981863 chr5:30019578-30019579(+) m6A 3'UTR       24981863 chr5:30019648-30019649(+) m6A 3'UTR       24981863 chr5:30019669-30019670(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-27a-3p	Exosome Mouse metastatic mammary carcinoma cells (4T1)|Non-tumorigenic mouse mammary epithelial cells (NMuMG)     25446899 Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Nucleus Liver cells     21862971

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-27a-3p
Interactor2: Il6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32552669	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Mice brain tissues	Interactor2 expression	None
Description	The circRNA-miRNA-mRNA ceRNA network.In total, we detected 569 negatively regulated miRNA-circRNA pairs and 2719 negatively regulated miRNA-mRNA pairs (Additional file 6: Table S5).