Basic Information:

  VIRBase ID:  

HHID00019755

  Virus:  

Japanese encephalitis virus

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-9-5p:  MIMAT0000441          IL6:  NM_001318095     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-9-5p	IL6
miRBase Accession/Entrez ID	MIMAT0000441	3569
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-9-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293)     22984580 Nucleus Nasopharyngeal carcinoma cells     20498841
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-9-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant Iodine Green 9956454 Drug sensitive 7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive 2-Methylthio-1,4-naphthoquinone 96324 Drug resistant 5-Iodo-8-quinolinol 96111 Drug sensitive Acnistin F 6712173 Drug resistant Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive 5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant Kijanimicin sodium salt 54707591 Drug sensitive Antineoplastic-643001 5466797 Drug sensitive Di-p-tolyliodinium bromide 54601177 Drug sensitive Simvastatin 54454 Drug sensitive Vorinostat 5311 Drug sensitive Eupachlorin 5281446 Drug resistant Spiperone 5265 Drug resistant Pipamperone 4830 Drug sensitive Tiazofurin 457954 Drug sensitive 5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug sensitive Suavedol 442245 Drug sensitive Triciribine phosphate 43860 Drug resistant Antibiotic X-14766A 434840 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive 11-Hydroxyusambarine Chlorhydrate 401426 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Stereoisomer of NSC 674066-O 384359 Drug sensitive 2-Ethylaminoestradiol 384235 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug sensitive Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug sensitive 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive Hexachlorophene 3598 Drug sensitive 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive L-Cysteine, S-[bis(4-methylphenyl)phenylmethyl]- 275979 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive 1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea 23634407 Drug sensitive 4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant 2,2'-Bioxirane 11254 Drug sensitive Waol A FD-211 10354084 Drug resistant 4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant o-linoleoyl-6-d-glucose - Drug resistant sphinxolide f - Drug resistant 1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive 2-(4-(methylsulfonyl)phenyl)-6-p-tolyl-4,5-dihydropyridazin-3(2H)-one - Drug sensitive 2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug sensitive 3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive Basic Fuchsin - Drug sensitive Camptothecin Derivative - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-9-5p	Rucaparib phosphate 9931953 Drug interaction    RC00003010 Formaldehyde 712 Drug interaction    RC00002988 Gemcitabine 60750 Drug interaction    RC00003004 Vincristine 5978 Drug interaction    RC00002997 D-Glucose 5793 Drug interaction    RC00002996 Estradiol 5757 Drug interaction    RC00002995 Prednisolone 5755 Drug interaction    RC00002994 Temozolomide 5394 Drug interaction    RC00002993 Sulindac sulfide 5352624 Drug interaction    RC00003009 Eloxatine 5310940 Drug interaction    RC00003008 Imatinib 5291 Drug interaction    RC00002992 Fenretinide 5288209 Drug interaction    RC00003007 Goserelinacetate 47725 Drug interaction    RC00003003 Diethylstilbestrol 448537 Drug interaction    RC00003006 Etoposide 36462 Drug interaction    RC00003002 Paclitaxel 36314 Drug interaction    RC00003001 Doxorubicin 31703 Drug interaction    RC00003000 Daunorubicin 30323 Drug interaction    RC00002999 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002991 Carmustine 2578 Drug interaction    RC00002990 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol 25262965 Drug interaction    RC00003011 Bicalutamide 2375 Drug interaction    RC00002989 Arsenic trioxide 14888 Drug interaction    RC00002998 Docetaxel 148124 Drug interaction    RC00003005 Asparaginase Escherichia coli - Drug interaction    RC00003012 TRAIL therapy - Drug interaction    RC00003013 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003014 Iron-sulfates and Aluminum-sulfates - Drug interaction    RC00003015

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-9-5p
Interactor2: IL6

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	miRNA array
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31578247	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	hNPC cells//hNS1 cells	Interactor2 expression	Upregulation
Description	FIG 6.qRT-PCR showing miR-9-5p target gene expression in hNS1 and hNP cells upon JEV infection and miR mimic transfection.FIG S3.Effect of miR-9-5p inhibitor treatment on target gene expression in both hNS1 and hNP cells.