Detail Information

Basic Information:


  VIRBase ID:  

HHID00019477

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:           BACH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p BACH1
miRBase
Accession/Entrez ID		 MIMAT0000421 571
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BACH-1//BTBD24

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BACH1
chr21:30724971(+) A-I      ncRNA
chr21:30730859(+) A-I      intronic
chr21:30730865(+) A-I      intronic
chr21:30730874(+) A-I      intronic
chr21:30730900(+) A-I      intronic
chr21:30731002(+) A-I      intronic
chr21:30731011(+) A-I      intronic
chr21:30710135(+) A-I      intronic
chr21:30724515(+) A-I      intronic
chr21:30731043(+) A-I      intronic
chr21:30724443(+) A-I      intronic
chr21:30730909(+) A-I      intronic
chr21:30730903(+) A-I      intronic
chr21:30724637(+) A-I      intronic
chr21:30730901(+) A-I      intronic
chr21:30730910(+) A-I      intronic
chr21:30731074(+) A-I      intronic
chr21:30731018(+) A-I      intronic
chr21:30731016(+) A-I      intronic
chr21:30730967(+) A-I      intronic
chr21:30730875(+) A-I      intronic
chr21:30712017(+) A-I      intronic
chr21:30712018(+) A-I      intronic
chr21:30712167(+) A-I      intronic
chr21:30725126(+) A-I      intronic
chr21:30724395(+) A-I      intronic
chr21:30725286(+) A-I      intronic
chr21:30725133(+) A-I      intronic
chr21:30724493(+) A-I      intronic
chr21:30724550(+) A-I      intronic
chr21:30730899(+) A-I      intronic
chr21:30730884(+) A-I      intronic
chr21:30730835(+) A-I      intronic
chr21:30724972(+) A-I      ncRNA
chr21:30710129(+) A-I      intronic
chr21:30731006(+) A-I      intronic
chr21:30730946(+) A-I      intronic
chr21:30725217(+) A-I      intronic
chr21:30710829(+) A-I      intronic
chr21:30725353(+) A-I      intronic
chr21:30730941(+) A-I      intronic
chr21:30724450(+) A-I      intronic
chr21:30724559(+) A-I      intronic
chr21:30710758(+) A-I      intronic
chr21:30724476(+) A-I      intronic
chr21:30724509(+) A-I      intronic
chr21:30725088(+) A-I      intronic
chr21:30730950(+) A-I      intronic
chr21:30724475(+) A-I      intronic
chr21:30725442(+) A-I      intronic
chr21:30710835(+) A-I      intronic
chr21:30730808(+) A-I      intronic
chr21:30725084(+) A-I      intronic
chr21:30725308(+) A-I      intronic
chr21:30730896(+) A-I      intronic
chr21:30710718(+) A-I      intronic
chr21:30730940(+) A-I      intronic
chr21:30725296(+) A-I      intronic
chr21:30730914(+) A-I      intronic
chr21:30725172(+) A-I      intronic
chr21:30710205(+) A-I      intronic
chr21:30724942(+) A-I      ncRNA
chr21:30724981(+) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BACH1
chr21:30710726(+) A-I intron -    22327324
chr21:30710726(+) A-G intron -    22484847
chr21:30725281(+) A-G intron -    22484847
chr21:30725296(+) A-G intron -    22484847
chr21:30725308(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BACH1
chr21:30660396-30660397(+) m6A 5'UTR//intron       24981863
chr21:30693726-30693727(+) m6A CDS       24284625
chr21:30698539-30698540(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698551-30698552(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698601-30698602(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698612-30698613(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698626-30698627(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698643-30698644(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698685-30698686(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698699-30698700(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698746-30698747(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698760-30698761(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698850-30698851(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30698887-30698888(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699005-30699006(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699091-30699092(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699101-30699102(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699169-30699170(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699222-30699223(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699329-30699330(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699370-30699371(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699422-30699423(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699485-30699486(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699498-30699499(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr21:30701937-30701938(+) m6A CDS       24209618//22608085
chr21:30701971-30701972(+) m6A CDS       24284625//24209618//22608085
chr21:30714779-30714780(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714789-30714790(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714799-30714800(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714841-30714842(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714931-30714932(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30715002-30715003(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr21:30715081-30715082(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715154-30715155(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715175-30715176(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715326-30715327(+) m6A 3'UTR//intron       24209618//24981863//22608085
chr21:30715383-30715384(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715392-30715393(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715463-30715464(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715478-30715479(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715499-30715500(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715809-30715810(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715902-30715903(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715948-30715949(+) m6A 3'UTR//intron       24981863
chr21:30718077-30718078(+) m6A 3'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084
BACH1
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: BACH1

Evidence Support:


Strong-Evidence qRT-PCR//Western blot
Support Database ViRBase

References:


PMID 17919492 Target region 5'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Huh7 cells Interactor2 expression Downregulation
Description To determine whether miR-122 regulates the expression of HO-1/Bach1 in hepatocytes, we employed antagomir of miR-122 to inactivate miR-122 in Huh-7 WT and 9-13 cells. Transfection of 50nM miR-122 antagomir into 9-13 cells for 72 hours significantly down-regulates the levels of Bach1 mRNAs by 53% (Fig. 5A, P<0.05) and up-regulates the levels of HO-1 mRNA 2.2-fold as expected (Fig. 5B, P<0.05).

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