Detail Information

Basic Information:


  VIRBase ID:  

HHID00019455

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-5p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-5p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000067 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-5p
rs1156338084 chr9:94176368    T/C
rs1421386283 chr9:94176365    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Human milk     28688106
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Plasma     24937531
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7f-5p
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug sensitive
Artelastin 399488 Drug resistant
Salarin C 24867082 Drug resistant
Epilactose 128037 Drug resistant
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
organosulfur compound - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7f-5p
Formaldehyde 712 Drug interaction    RC00000304
Bisphenol A 6623 Drug interaction    RC00000311
Gemcitabine 60750 Drug interaction    RC00000315
Estradiol 5757 Drug interaction    RC00000310
Imatinib 5291 Drug interaction    RC00000309
Cholecalciferol 5280795 Drug interaction    RC00000319
Decitabine 451668 Drug interaction    RC00000318
Oleic acid 445639 Drug interaction    RC00000317
Docosahexaenoic acid 445580 Drug interaction    RC00000316
Letrozole 3902 Drug interaction    RC00000308
5-Fluorouracil 3385 Drug interaction    RC00000307
Doxorubicin 31703 Drug interaction    RC00000314
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000306
Verapamil 2520 Drug interaction    RC00000305
Arsenic trioxide 14888 Drug interaction    RC00000313
Hesperidin 10621 Drug interaction    RC00000312
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000320

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-5p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 20969775 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Con1 cells Interactor2 expression None
Description The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.

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