Detail Information

Basic Information:


  VIRBase ID:  

HHID00019436

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           IL6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p IL6
miRBase
Accession/Entrez ID		 MIMAT0004593 3569
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: IL6

Evidence Support:


Strong-Evidence qRT-PCR
Support Database ViRBase

References:


PMID 30974864 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description The selected six upregulated genes following miR-130a overexpression: (E) DHX58; (F) CD86; (G) IL6; (H) MX1; (I) PYCARD; and (J) TLR7.

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