Basic Information:

  VIRBase ID:  

HHID00019395

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:  MIMAT0000421          HNF4A:  NM_175914     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-122-5p	HNF4A
miRBase Accession/Entrez ID	MIMAT0000421	3172
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FRTS4//HNF4//HNF4a7//HNF4a8//HNF4a9//HNF4alpha//MODY//MODY1//NR2A1//NR2A21//TCF//TCF14

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-122-5p	rs1258166649 chr18:58451088    T/C rs1426570658 chr18:58451093    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HNF4A	chr20:43037293(+) A-I      intronic chr20:43038603(+) A-I      intronic chr20:43038747(+) A-I      intronic chr20:43038607(+) A-I      intronic chr20:43053834(+) A-I      intronic chr20:43037256(+) A-I      intronic chr20:43050300(+) A-I      intronic chr20:43051728(+) A-I      intronic chr20:43051747(+) A-I      intronic chr20:43051781(+) A-I      intronic chr20:43051809(+) A-I      intronic chr20:43006217(+) A-I      intronic chr20:43053685(+) A-I      intronic chr20:43054500(+) A-I      intronic chr20:43055291(+) A-I      intronic chr20:43055402(+) A-I      intronic chr20:43055349(+) A-I      intronic chr20:43055320(+) A-I      intronic chr20:43055292(+) A-I      intronic chr20:43054509(+) A-I      intronic chr20:43053866(+) A-I      intronic chr20:43054388(+) A-I      intronic chr20:43054456(+) A-I      intronic chr20:43051862(+) A-I      intronic chr20:43007037(+) A-I      intronic chr20:43051888(+) A-I      intronic chr20:43051881(+) A-I      intronic chr20:43015821(+) A-I      intronic chr20:43050165(+) A-I      intronic chr20:43053858(+) A-I      intronic chr20:43054561(+) A-I      intronic chr20:43053751(+) A-I      intronic chr20:43054407(+) A-I      intronic chr20:43055368(+) A-I      intronic chr20:42990909(+) A-I      intronic chr20:43054539(+) A-I      intronic chr20:43054424(+) A-I      intronic chr20:43055327(+) A-I      intronic chr20:43053646(+) A-I      intronic chr20:43054562(+) A-I      intronic chr20:43051432(+) A-I      intronic chr20:42997991(+) A-I      intronic chr20:43040514(+) A-I      intronic chr20:43054421(+) A-I      intronic chr20:42990913(+) A-I      intronic chr20:43055234(+) A-I      intronic chr20:43055336(+) A-I      intronic chr20:43055224(+) A-I      intronic chr20:43051458(+) A-I      intronic chr20:43053647(+) A-I      intronic chr20:43054538(+) A-I      intronic chr20:43053657(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HNF4A	chr20:43030027-43030028(+) m6A CDS//intron       24981863 chr20:43058404-43058405(+) m6A 3'UTR       24981863 chr20:43058446-43058447(+) m6A 3'UTR       24284625//24981863//26404942 chr20:43058504-43058505(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535 chr20:43058520-43058521(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535 chr20:43058536-43058537(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535 chr20:43058613-43058614(+) m6A 3'UTR       24284625//24981863//26404942//27773535 chr20:43058648-43058649(+) m6A 3'UTR       24284625//24981863//27773535 chr20:43058711-43058712(+) m6A 3'UTR       24981863 chr20:43058894-43058895(+) m6A 3'UTR       24981863//26404942 chr20:43058917-43058918(+) m6A 3'UTR       24981863//26404942 chr20:43059002-43059003(+) m6A 3'UTR       25456834//24981863 chr20:43059053-43059054(+) m6A 3'UTR       25456834//24981863//27773535 chr20:43059082-43059083(+) m6A 3'UTR       25456834//24981863//27773535 chr20:43059119-43059120(+) m6A 3'UTR       25456834//24981863//27773535 chr20:43059179-43059180(+) m6A 3'UTR       24981863//27773535 chr20:43059191-43059192(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43059305-43059306(+) m6A 3'UTR       24981863//27773535 chr20:43059369-43059370(+) m6A 3'UTR       24981863 chr20:43059470-43059471(+) m6A 3'UTR       24981863 chr20:43059483-43059484(+) m6A 3'UTR       24981863 chr20:43059747-43059748(+) m6A 3'UTR       24981863//27773535 chr20:43059778-43059779(+) m6A 3'UTR       24981863//27773535 chr20:43059784-43059785(+) m6A 3'UTR       24981863//27773535 chr20:43059806-43059807(+) m6A 3'UTR       24981863//27773535 chr20:43059911-43059912(+) m6A 3'UTR       24981863 chr20:43059916-43059917(+) m6A 3'UTR       24981863 chr20:43059932-43059933(+) m6A 3'UTR       24981863 chr20:43059950-43059951(+) m6A 3'UTR       24981863 chr20:43060137-43060138(+) m6A 3'UTR       24981863 chr20:43060202-43060203(+) m6A 3'UTR       24981863 chr20:43060235-43060236(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43060291-43060292(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43060322-43060323(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43060371-43060372(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43060379-43060380(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43060920-43060921(+) m6A 3'UTR       27773535 chr20:43060927-43060928(+) m6A 3'UTR       27773535 chr20:43061032-43061033(+) m6A 3'UTR       24981863 chr20:43061048-43061049(+) m6A 3'UTR       24981863 chr20:43061071-43061072(+) m6A 3'UTR       24981863 chr20:43061100-43061101(+) m6A 3'UTR       24981863 chr20:43061164-43061165(+) m6A 3'UTR       24981863 chr20:43061409-43061410(+) m6A 3'UTR       27773535 chr20:43061416-43061417(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-122-5p	Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196 Cytoplasm Huh-7 cells     29486652 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Huh-7 cells     26304123 Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950 Exosome B cell line (Raji)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|Chronic lymphocytic leukemia cells     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196 Nucleus Nasopharyngeal carcinoma cells     20498841 Polysome Human cervical cancer cell line (HeLa)     25609084
	HNF4A	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-122-5p
Interactor2: HNF4A

Evidence Support:

Strong-Evidence	qPCR//Western blot
Support Database	ViRBase

References:

PMID	31363036	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Huh7 cells	Interactor2 expression	None
Description	HCV downregulates HNF4A expression to reduce miR-122 transcription.