Detail Information

Basic Information:


  VIRBase ID:  

HHID00019386

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-148a-3p:           IL6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-148a-3p IL6
miRBase
Accession/Entrez ID		 MIMAT0000243 3569
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-148a-3p
rs1249161151 chr7:25949928    T/C
rs370090919 chr7:25949933    T/A
rs370090919 chr7:25949933    T/C
rs748063984 chr7:25949925    A/G
rs771952261 chr7:25949931    T/C
rs771952261 chr7:25949931    T/G
rs774196394 chr7:25949923    C/G
rs1290582082 chr7:25949936    T/C
rs772747528 chr7:25949942    G/A
rs772747528 chr7:25949942    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-148a-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Saliva     25376581
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-148a-3p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug resistant
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug resistant
Tiotixene 941651 Drug sensitive
Dichlorodipropylstannane 93562 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
Verrucarin A 6326658 Drug sensitive
Methylene blue 6099 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Caracemide 54747 Drug sensitive
Aspiculamycin hcl 54600418 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug sensitive
Entinostat 4261 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
Cycloalkannin 375418 Drug sensitive
3-Deazaneplanocin hydrochloride 358176 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Dasatinib 3062316 Drug resistant
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
D-Arabinose, 5-O-trityl-tribenzoate 265952 Drug sensitive
Cytembena 23665583 Drug sensitive
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug resistant
8-Hydroxyquinoline 1923 Drug sensitive
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Methyl (7E,9Z,11R,12S,13R,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-12,14,18,19,31-pentahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319083 Drug sensitive
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
(1S,2S,11R,15S,18S)-9,10,15,18-Tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 134694721 Drug sensitive
[(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant
Dibutyltin dichloride 12688 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
Chimaphilin 101211 Drug sensitive
Cyanocycline A 100158 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug resistant
antineoplastic-d655481 - Drug resistant
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive
7-propanoyltaxol - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-148a-3p
Curcumin 969516 Drug interaction    RC00001590
Bilobalide 73581 Drug interaction    RC00001585
Oxaliplatine 6857599 Drug interaction    RC00001592
Fludarabine 657237 Drug interaction    RC00001589
Gemcitabine 60750 Drug interaction    RC00001584
Cholesterol 5997 Drug interaction    RC00001577
Vincristine 5978 Drug interaction    RC00001576
D-Glucose 5793 Drug interaction    RC00001575
Dexamethasone 5743 Drug interaction    RC00001574
Imatinib 5291 Drug interaction    RC00001573
Daidzein 5281708 Drug interaction    RC00001591
Goserelinacetate 47725 Drug interaction    RC00001583
Paroxetine 43815 Drug interaction    RC00001582
Paclitaxel 36314 Drug interaction    RC00001581
5-Fluorouracil 3385 Drug interaction    RC00001572
Doxorubicin 31703 Drug interaction    RC00001580
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001571
Celecoxib 2662 Drug interaction    RC00001570
Verapamil 2520 Drug interaction    RC00001569
17-Hydroxyandrostan-3-one 15 Drug interaction    RC00001568
Arsenic trioxide 14888 Drug interaction    RC00001579
Docetaxel 148124 Drug interaction    RC00001588
Leucovorin 135403648 Drug interaction    RC00001593
Vinblastine 13342 Drug interaction    RC00001578
Gefitinib 123631 Drug interaction    RC00001587
Ginsenoside Rh2 119307 Drug interaction    RC00001586
Chemotherapy - Drug interaction    RC00008830
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001594
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-148a-3p
Cisplatin 5702198       28965855
Cisplatin 5702198       30510209
5-Fluorouracil 3385       30510209
Doxorubicin 31703       24759738
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-148a-3p
Interactor2: IL6

Evidence Support:


Strong-Evidence qRT-PCR
Support Database ViRBase

References:


PMID 30565389 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression Upregulation
Description MiR‐148a‐3p regulated the expression of c‐Jun, IL‐6, MMP‐9, MMP‐13, TNF‐alpha and IL‐1alpha mRNA and affected proliferation, cell cycle and apoptosis. As shown in Figure 6C‐G, the expression levels of inflammation‐related IL‐6, MMP‐9, MMP‐13, TNF‐alpha and IL‐1alpha mRNA were all increased by miR‐148a‐3p inhibitor (P < 0.05).

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