Detail Information

Basic Information:


  VIRBase ID:  

HHID00019067

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196a-5p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-196a-5p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000226 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-196a-5p
rs1422312414 chr17:48632534    C/CA
rs190478598 chr17:48632537    C/A
rs372978481 chr17:48632533    C/T
rs751887895 chr17:48632536    A/G
rs931027203 chr17:48632541    A/G
rs931027203 chr17:48632541    A/T
rs1289240119 chr12:53991783    G/A
rs1449318187 chr12:53991762    T/A
rs185070757 chr12:53991774    T/G
rs569910454 chr12:53991777    T/C
rs750731061 chr12:53991771    T/A
rs750731061 chr12:53991771    T/C
rs755062780 chr12:53991778    G/A
rs755062780 chr12:53991778    G/T
rs756640169 chr12:53991773    A/G
rs756640169 chr12:53991773    A/T
rs1167097656 chr17:48632550    C/T
rs767877229 chr12:53991765    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-196a-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Serum     18589210
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Colon tissue|Tongue tissue     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Hepatoma cells     23771658
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-196a-5p
TCS JNK 5a 766949 Drug sensitive
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
bisarylpurine - Drug resistant
1-[(4-aminophenyl)-(4-hydroxyphenyl)methylidene]-[3]ferrocenophane - Drug sensitive
Camptothecin Derivative - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-196a-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00001465
Curcumin 969516 Drug interaction    RC00001473
Eloxatine 5310940 Drug interaction    RC00001475
Imatinib 5291 Drug interaction    RC00001462
Diethylstilbestrol 448537 Drug interaction    RC00001472
Naringin 442428 Drug interaction    RC00001471
Mechlorethamine 4033 Drug interaction    RC00001461
Doxorubicin 31703 Drug interaction    RC00001464
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001460
Tamoxifen 2733526 Drug interaction    RC00001474
Verapamil 2520 Drug interaction    RC00001459
Sorafenib 216239 Drug interaction    RC00001470
Polylysine 162282 Drug interaction    RC00001469
Arsenic trioxide 14888 Drug interaction    RC00001463
Docetaxel 148124 Drug interaction    RC00001468
Proanthocyanidin 108065 Drug interaction    RC00001467
Fulvestrant 104741 Drug interaction    RC00001466
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001476
Trypaflavine - Drug interaction    RC00001477
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-196a-5p
Gemcitabine 60750       27591936
Cisplatin 5702198       27591936

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-196a-5p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence TaqMan qRT-PCR
Support Database VIRmiRNA

References:


PMID 21070682 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line PBMCs Interactor2 expression None
Description Our analysis revealed that the levels of expression of all miRNAs investigated in patients with CHC were different to those in healthy individuals. When levels of the miRNAs were measured 12 hours after the first IFN injection, increases in expression levels of IFN-induced miRNAs were observed in 25-50% of patients, depending on the type of miRNA examined.

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