Basic Information
RNALocate ID: RLID:11001259
RNA Symbol: hsa-miR-196a-5p
Localization: Exosome
RNA Information
RNA Name: hsa-miR-196a
RNA ID: miRBase:MIMAT0000226
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 20615901
Tissue/Cell Line: Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)
Method: Microarray|RT-PCR

Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001548 Cytoplasm Nasopharyngeal carcinoma cells 20498841
RLID:01001549 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001550 Mitochondrion Skeletal muscle myoblasts 21637849
RLID:01001551 Mitochondrion Cell line (HEK-293|HeLa) 22984580
RLID:01001552 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001553 Nucleus Nasopharyngeal carcinoma cells 20498841
RLID:11001257 Exosome Human cervical cancer cell line (HeLa) 25760330
RLID:11001258 Exosome Serum 18589210
RLID:11001260 Exosome Jurkat-derived T cell line (J77cl20) 21505438
RLID:11001261 Exosome Brain tissue 23382797
RLID:11001262 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) 20615901
RLID:11001263 Microvesicle Hepatoma cells 23771658
RLID-D:11000037 Exosome Colon tissue|Tongue tissue
RLID-D:11000305 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-miR-196a-5p Multiple sclerosis chronic progressive MNDR-E-MI-23970
MNDR hsa-miR-196a-5p Oral squamous cell carcinoma MNDR-E-MI-23971
MNDR hsa-miR-196a-5p Large cell neuroendocrine cancer MNDR-E-MI-23972
MNDR hsa-miR-196a-5p Follicular cleaved lymphoma MNDR-E-MI-23973
MNDR hsa-miR-196a-5p Lymphoma MNDR-E-MI-23974
MNDR hsa-miR-196a-5p Non-hodgkin lymphoma MNDR-E-MI-23975
MNDR hsa-miR-196a-5p Estrogen-receptor positive breast cancer MNDR-E-MI-23976
MNDR hsa-miR-196a-5p Progesterone-receptor positive breast cancer MNDR-E-MI-23977
MNDR hsa-miR-196a-5p Progesterone-receptor negative breast cancer MNDR-E-MI-23978
MNDR hsa-miR-196a-5p Her2-receptor positive breast cancer MNDR-E-MI-23979
MNDR hsa-miR-196a-5p Breast cancer luminal MNDR-E-MI-23980
MNDR hsa-miR-196a-5p Niemann-pick disease type c MNDR-E-MI-23981
MNDR hsa-miR-196a-5p Small intestine cancer MNDR-E-MI-23982
MNDR hsa-miR-196a-5p Prostate cancer MNDR-E-MI-23983
MNDR hsa-miR-196a-5p Chronic lymphocytic leukemia MNDR-E-MI-23984
MNDR hsa-miR-196a-5p Gastric cancer MNDR-E-MI-23985
MNDR hsa-miR-196a-5p Adrenoleukodystrophy MNDR-E-MI-23986
MNDR hsa-miR-196a-5p Intracranial aneurysm MNDR-E-MI-23987
MNDR hsa-miR-196a-5p Esophageal carcinoma MNDR-E-MI-23988
MNDR hsa-miR-196a-5p Heart disease MNDR-E-MI-23989
MNDR hsa-miR-196a-5p Head and neck cancer MNDR-E-MI-23990
MNDR hsa-miR-196a-5p Vitiligo MNDR-E-MI-23991
MNDR hsa-miR-196a-5p Leukemia MNDR-E-MI-23992
MNDR hsa-miR-196a-5p Acute leukemia MNDR-E-MI-23993
MNDR hsa-miR-196a-5p Huntington disease MNDR-E-MI-23994
MNDR hsa-miR-196a-5p Chorea MNDR-E-MI-23995
MNDR hsa-miR-196a-5p Lung cancer MNDR-E-MI-23996
MNDR hsa-miR-196a-5p Down syndrome MNDR-E-MI-23997
MNDR hsa-miR-196a-5p Parkinson disease MNDR-E-MI-23998
MNDR hsa-miR-196a-5p Niemann-pick disease MNDR-E-MI-23999
MNDR hsa-miR-196a-5p Breast cancer MNDR-E-MI-24000
MNDR hsa-miR-196a-5p Congenital heart disease MNDR-E-MI-24001
MNDR hsa-miR-196a-5p Neuroendocrine neoplasia MNDR-E-MI-24002
MNDR hsa-miR-196a-5p Pancreatic cancer MNDR-E-MI-24003
MNDR hsa-miR-196a-5p Pancreatic endocrine carcinoma MNDR-E-MI-24004
MNDR hsa-miR-196a-5p Malignant melanoma MNDR-E-MI-24005
MNDR hsa-miR-196a-5p Rectum adenocarcinoma MNDR-E-MI-24006
MNDR hsa-miR-196a-5p Colon cancer MNDR-E-MI-24007
MNDR hsa-miR-196a-5p Colon adenocarcinoma MNDR-E-MI-24008
MNDR hsa-miR-196a-5p Multiple sclerosis relapsing-remitting MNDR-E-MI-24009
MNDR hsa-miR-196a-5p Familial ovarian cancer MNDR-E-MI-24010
MNDR hsa-miR-196a-5p Prostate adenocarcinoma MNDR-E-MI-24011
MNDR hsa-miR-196a-5p Endometriosis MNDR-E-MI-24012
MNDR hsa-miR-196a-5p Pulmonary tuberculosis MNDR-E-MI-24013
MNDR hsa-miR-196a-5p Carcinoma ductal breast MNDR-E-MI-24014
MNDR hsa-miR-196a-5p Glioblastoma MNDR-E-MI-24015
MNDR hsa-miR-196a-5p Glioma MNDR-E-MI-24016
MNDR hsa-miR-196a-5p Osteosarcoma MNDR-E-MI-24017
MNDR hsa-miR-196a-5p Breast carcinoma MNDR-E-MI-24018
MNDR hsa-miR-196a-5p Pancreatic ductal adenocarcinoma MNDR-E-MI-24019
MNDR hsa-miR-196a-5p Uterus cancer MNDR-E-MI-24020
MNDR hsa-miR-196a-5p Gastric adenocarcinoma MNDR-E-MI-24021
MNDR hsa-miR-196a-5p Pituitary adenoma MNDR-E-MI-24022
MNDR hsa-miR-196a-5p Lung squamous cell carcinoma MNDR-E-MI-24023
MNDR hsa-miR-196a-5p Non-small cell lung cancer MNDR-E-MI-24024
MNDR hsa-miR-196a-5p Lung adenocarcinoma MNDR-E-MI-24025
MNDR hsa-miR-196a-5p Adrenocortical carcinoma MNDR-E-MI-24026
MNDR hsa-miR-196a-5p Thyroid carcinoma MNDR-E-MI-24027
MNDR hsa-miR-196a-5p Pancreatic adenocarcinoma MNDR-E-MI-24028
MNDR hsa-miR-196a-5p Scleroderma MNDR-E-MI-24029
MNDR hsa-miR-196a-5p Carcinoma renal cell MNDR-E-MI-24030
MNDR hsa-miR-196a-5p Renal clear cell carcinoma MNDR-E-MI-24031
MNDR hsa-miR-196a-5p Biliary tract cancer MNDR-E-MI-24032
MNDR hsa-miR-196a-5p Esophageal adenocarcinoma MNDR-E-MI-24033
MNDR hsa-miR-196a-5p Cholangiocarcinoma MNDR-E-MI-24034
MNDR hsa-miR-196a-5p Esophageal cancer MNDR-E-MI-24035
MNDR hsa-miR-196a-5p Infertility MNDR-E-MI-24036
MNDR hsa-miR-196a-5p Lung small cell carcinoma MNDR-E-MI-24037
MNDR hsa-miR-196a-5p Head and neck squamous cell carcinoma MNDR-E-MI-24038
MNDR hsa-miR-196a-5p Testicular germ cell cancer MNDR-E-MI-24039
MNDR hsa-miR-196a-5p Growth hormone-secreting pituitary adenoma MNDR-E-MI-24040
MNDR hsa-miR-196a-5p Breast invasive carcinoma MNDR-E-MI-24041
MNDR hsa-miR-196a-5p Hepatocellular carcinoma MNDR-E-MI-24042
MNDR hsa-miR-196a-5p Embryonal cancer MNDR-E-MI-24043
MNDR hsa-miR-196a-5p Familiar ovarian carcinoma MNDR-E-MI-24044
MNDR hsa-miR-196a-5p B-cell lymphoma MNDR-E-MI-24045
MNDR hsa-miR-196a-5p Retinoblastoma MNDR-E-MI-24046
MNDR hsa-miR-196a-5p Barrett's adenocarcinoma MNDR-E-MI-24047
MNDR hsa-miR-196a-5p Hodgkin lymphoma MNDR-E-MI-24048
MNDR hsa-miR-196a-5p Mouth neoplasms MNDR-E-MI-24049
MNDR hsa-miR-196a-5p Crohn disease MNDR-E-MI-24050
MNDR hsa-miR-196a-5p Tonsil cancer MNDR-E-MI-24051
MNDR hsa-miR-196a-5p Neuromyelitis optica MNDR-E-MI-24052
MNDR hsa-miR-196a-5p Gastrointestinal stromal tumor MNDR-E-MI-24053
MNDR hsa-miR-196a-5p Colorectal cancer MNDR-E-MI-24054
MNDR hsa-miR-196a-5p Type 2 diabetes mellitus MNDR-E-MI-24055
MNDR hsa-miR-196a-5p Multiple myeloma MNDR-E-MI-24056
MNDR hsa-miR-196a-5p Ependymoma MNDR-E-MI-24057
MNDR hsa-miR-196a-5p Prostatic neoplasms MNDR-E-MI-24058
MNDR hsa-miR-196a-5p Hypersomnolence idiopathic MNDR-E-MI-24059
MNDR hsa-miR-196a-5p Stroke MNDR-E-MI-24060
MNDR hsa-miR-196a-5p Stroke lacunar MNDR-E-MI-24061
MNDR hsa-miR-196a-5p Barrett's carcinogenesis MNDR-E-MI-24062
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter ANXA1 Homo sapiens RR00084307
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