Basic Information:

  VIRBase ID:  

HHID00019066

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196a-5p:  MIMAT0000226          HMOX1:  NM_002133     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-196a-5p	HMOX1
miRBase Accession/Entrez ID	MIMAT0000226	3162
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bK286B10//HMOX1D//HO-1//HSP32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-196a-5p	rs1422312414 chr17:48632534    C/CA rs190478598 chr17:48632537    C/A rs372978481 chr17:48632533    C/T rs751887895 chr17:48632536    A/G rs931027203 chr17:48632541    A/G rs931027203 chr17:48632541    A/T rs1289240119 chr12:53991783    G/A rs1449318187 chr12:53991762    T/A rs185070757 chr12:53991774    T/G rs569910454 chr12:53991777    T/C rs750731061 chr12:53991771    T/A rs750731061 chr12:53991771    T/C rs755062780 chr12:53991778    G/A rs755062780 chr12:53991778    G/T rs756640169 chr12:53991773    A/G rs756640169 chr12:53991773    A/T rs1167097656 chr17:48632550    C/T rs767877229 chr12:53991765    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HMOX1	chr22:35787954(+) A-I      intronic chr22:35784679(+) A-I      intronic chr22:35788097(+) A-I      intronic chr22:35788149(+) A-I      intronic chr22:35788106(+) A-I      intronic chr22:35788102(+) A-I      intronic chr22:35784669(+) A-I      intronic chr22:35787541(+) A-I      intronic chr22:35784711(+) A-I      intronic chr22:35785510(+) A-I      intronic chr22:35785529(+) A-I      intronic chr22:35785535(+) A-I      intronic chr22:35787308(+) A-I      intronic chr22:35787342(+) A-I      intronic chr22:35787420(+) A-I      intronic chr22:35787446(+) A-I      intronic chr22:35787699(+) A-I      intronic chr22:35787717(+) A-I      intronic chr22:35787944(+) A-I      intronic chr22:35787963(+) A-I      intronic chr22:35788007(+) A-I      intronic chr22:35788096(+) A-I      intronic chr22:35788023(+) A-I      intronic chr22:35788174(+) A-I      intronic chr22:35788167(+) A-I      intronic chr22:35785492(+) A-I      intronic chr22:35788137(+) A-I      intronic chr22:35785708(+) A-I      intronic chr22:35784186(+) A-I      intronic chr22:35787642(+) A-I      intronic chr22:35788849(+) A-I      intronic chr22:35784324(+) A-I      intronic chr22:35788031(+) A-I      intronic chr22:35786496(+) A-I      intronic chr22:35785601(+) A-I      intronic chr22:35785575(+) A-I      intronic chr22:35785602(+) A-I      intronic chr22:35787998(+) A-I      intronic chr22:35788008(+) A-I      intronic chr22:35785637(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HMOX1	chr22:35790022(+) T-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMOX1	chr22:35777264-35777265(+) m6A exon//intron       24284625//24981863//26404942 chr22:35777300-35777301(+) m6A exon//intron       24981863//26404942 chr22:35779181-35779182(+) m6A CDS//exon       24981863//26404942 chr22:35782807-35782808(+) m6A CDS//exon       26404942 chr22:35782999-35783000(+) m6A CDS       24284625//25456834//26404942 chr22:35783092-35783093(+) m6A CDS//exon       24284625//25456834//26404942 chr22:35783145-35783146(+) m6A CDS//exon       26404942 chr22:35785899-35785900(+) m6A CDS//exon       24284625//26404942 chr22:35786004-35786005(+) m6A exon//intron       24284625 chr22:35789477-35789478(+) m6A CDS       24284625//26404942 chr22:35789621-35789622(+) m6A 3'UTR       24284625//24981863//26404942 chr22:35789799-35789800(+) m6A 3'UTR       26404942 chr22:35789868-35789869(+) m6A 3'UTR       26404942 chr22:35789894-35789895(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-196a-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Serum     18589210 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Colon tissue|Tongue tissue     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Hepatoma cells     23771658 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	HMOX1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-196a-5p	TCS JNK 5a 766949 Drug sensitive dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant bisarylpurine - Drug resistant 1-[(4-aminophenyl)-(4-hydroxyphenyl)methylidene]-[3]ferrocenophane - Drug sensitive Camptothecin Derivative - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-196a-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00001465 Curcumin 969516 Drug interaction    RC00001473 Eloxatine 5310940 Drug interaction    RC00001475 Imatinib 5291 Drug interaction    RC00001462 Diethylstilbestrol 448537 Drug interaction    RC00001472 Naringin 442428 Drug interaction    RC00001471 Mechlorethamine 4033 Drug interaction    RC00001461 Doxorubicin 31703 Drug interaction    RC00001464 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001460 Tamoxifen 2733526 Drug interaction    RC00001474 Verapamil 2520 Drug interaction    RC00001459 Sorafenib 216239 Drug interaction    RC00001470 Polylysine 162282 Drug interaction    RC00001469 Arsenic trioxide 14888 Drug interaction    RC00001463 Docetaxel 148124 Drug interaction    RC00001468 Proanthocyanidin 108065 Drug interaction    RC00001467 Fulvestrant 104741 Drug interaction    RC00001466 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001476 Trypaflavine - Drug interaction    RC00001477

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-196a-5p	Gemcitabine 60750       27591936 Cisplatin 5702198       27591936

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-196a-5p
Interactor2: HMOX1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	23108868	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	9-13 cells//Huh7 cells//Huh7.5 cells	Interactor2 expression	Upregulation
Description	MiR-196 induction downregulates Bach1 and upregulates HMOX1 in human hepatoma 9-13 cells. Therefore, miR-196 plays a protective role in HCV-HCC by directly targeting HCV genomes or indirectly regulating Bach1 and HMOX1 expression/function.