Detail Information

Basic Information:


  VIRBase ID:  

HHID00013891

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           TRIM59:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 TRIM59
miRBase
Accession/Entrez ID		 MIMAT0005893 286827
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFT80L//MRF1//RNF104//TRIM57//TSBF1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM59
chr3:160161625(-) A-I      intronic
chr3:160163877(-) A-I      intronic
chr3:160153071(-) A-I      3'UTR
chr3:160161618(-) A-I      intronic
chr3:160161642(-) A-I      intronic
chr3:160161605(-) A-I      intronic
chr3:160160758(-) A-I      intronic
chr3:160163046(-) A-I      intronic
chr3:160154393(-) A-I      3'UTR
chr3:160163204(-) A-I      intronic
chr3:160163691(-) A-I      intronic
chr3:160163318(-) A-I      intronic
chr3:160153110(-) A-I      3'UTR
chr3:160154419(-) A-I      3'UTR
chr3:160154937(-) A-I      3'UTR
chr3:160153124(-) A-I      3'UTR
chr3:160153026(-) A-I      3'UTR
chr3:160153164(-) A-I      3'UTR
chr3:160153038(-) A-I      3'UTR
chr3:160153138(-) A-I      3'UTR
chr3:160153166(-) A-I      3'UTR
chr3:160153032(-) A-I      3'UTR
chr3:160154314(-) A-I      3'UTR
chr3:160155016(-) A-I      3'UTR
chr3:160160207(-) A-I      intronic
chr3:160163203(-) A-I      intronic
chr3:160163871(-) A-I      intronic
chr3:160163164(-) A-I      intronic
chr3:160163800(-) A-I      intronic
chr3:160161525(-) A-I      intronic
chr3:160163479(-) A-I      intronic
chr3:160163662(-) A-I      intronic
chr3:160161623(-) A-I      intronic
chr3:160163690(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM59
chr3:160154332(-) T-C exon 3'UTR    22484847
chr3:160154360(-) C-T exon 3'UTR    22484847
chr3:160154937(-) A-G exon 3'UTR    22484847
chr3:160154941(-) T-C exon 3'UTR    22484847
chr3:160154955(-) A-G exon 3'UTR    22484847
chr3:160161592(-) A-G intron -    22484847
chr3:160161623(-) A-G intron -    22484847
chr3:160161635(-) T-C intron -    22484847
chr3:160163121(-) A-G intron -    22484847
chr3:160163204(-) A-G intron -    22484847
chr3:160163479(-) A-G intron -    22484847
chr3:160163540(-) A-C intron -    22484847
chr3:160163870(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM59
chr3:160150879-160150880(-) m6A 3'UTR       27773535
chr3:160150973-160150974(-) m6A 3'UTR       27773535
chr3:160151433-160151434(-) m6A 3'UTR       24981863//27773535//22608085
chr3:160151465-160151466(-) m6A 3'UTR       24981863//27773535//22608085
chr3:160151495-160151496(-) m6A 3'UTR       24981863//27773535//22575960//22608085
chr3:160152260-160152261(-) m6A 3'UTR       27773535
chr3:160152292-160152293(-) m6A 3'UTR       27773535
chr3:160152554-160152555(-) m6A 3'UTR       27773535
chr3:160152615-160152616(-) m6A 3'UTR       27773535
chr3:160152638-160152639(-) m6A 3'UTR       27773535
chr3:160152664-160152665(-) m6A 3'UTR       27773535
chr3:160155979-160155980(-) m6A CDS//intron       25456834//24981863//27773535//22608085
chr3:160156086-160156087(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156097-160156098(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156170-160156171(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156176-160156177(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156380-160156381(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156464-160156465(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156499-160156500(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156521-160156522(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156530-160156531(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156543-160156544(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156674-160156675(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156702-160156703(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156827-160156828(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156864-160156865(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160165540-160165541(-) m6A 5'UTR//intron       24981863//22608085
chr3:160166529-160166530(-) m6A 5'UTR//CDS//intron       24209618//24981863//22608085
chr3:160166659-160166660(-) m6A 5'UTR//intron       24981863
chr3:160166693-160166694(-) m6A 5'UTR//intron       24981863
chr3:160167589-160167590(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TRIM59
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: TRIM59

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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