Basic Information:

  VIRBase ID:  

HHID00012107

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          CAPN1:  NR_040008     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	CAPN1
miRBase Accession/Entrez ID	MIMAT0004811	823
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CANP//CANP1//CANPL1//muCANP//muCL//SPG76

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPN1	chr11:64959543(+) A-I      intronic chr11:64959552(+) A-I      intronic chr11:64959553(+) A-I      intronic chr11:64965205(+) A-I      intronic chr11:64965219(+) A-I      intronic chr11:64959579(+) A-I      intronic chr11:64956553(+) A-I      intronic chr11:64965206(+) A-I      intronic chr11:64965681(+) A-I      intronic chr11:64959523(+) A-I      intronic chr11:64959527(+) A-I      intronic chr11:64967726(+) A-I      intronic chr11:64959542(+) A-I      intronic chr11:64967916(+) A-I      intronic chr11:64962751(+) A-I      intronic chr11:64959033(+) A-I      intronic chr11:64967919(+) A-I      intronic chr11:64965172(+) A-I      intronic chr11:64967981(+) A-I      intronic chr11:64969935(+) A-I      intronic chr11:64961272(+) A-I      intronic chr11:64955243(+) A-I      intronic chr11:64960278(+) A-I      intronic chr11:64970017(+) A-I      intronic chr11:64965228(+) A-I      intronic chr11:64960908(+) A-I      intronic chr11:64970018(+) A-I      intronic chr11:64965238(+) A-I      intronic chr11:64965244(+) A-I      intronic chr11:64970761(+) A-I      intronic chr11:64965265(+) A-I      intronic chr11:64965202(+) A-I      intronic chr11:64961513(+) A-I      intronic chr11:64960928(+) A-I      intronic chr11:64959611(+) A-I      intronic chr11:64965846(+) A-I      intronic chr11:64965193(+) A-I      intronic chr11:64959559(+) A-I      intronic chr11:64958301(+) A-I      intronic chr11:64959626(+) A-I      intronic chr11:64960939(+) A-I      intronic chr11:64965251(+) A-I      intronic chr11:64974770(+) A-I      intronic chr11:64961337(+) A-I      intronic chr11:64961326(+) A-I      intronic chr11:64962680(+) A-I      intronic chr11:64965280(+) A-I      intronic chr11:64960985(+) A-I      intronic chr11:64965162(+) A-I      intronic chr11:64965304(+) A-I      intronic chr11:64960979(+) A-I      intronic chr11:64967600(+) A-I      intronic chr11:64965274(+) A-I      intronic chr11:64959547(+) A-I      intronic chr11:64967633(+) A-I      intronic chr11:64967660(+) A-I      intronic chr11:64956624(+) A-I      intronic chr11:64958929(+) A-I      intronic chr11:64958919(+) A-I      intronic chr11:64967780(+) A-I      intronic chr11:64965086(+) A-I      intronic chr11:64958381(+) A-I      intronic chr11:64968181(+) A-I      intronic chr11:64962650(+) A-I      intronic chr11:64958367(+) A-I      intronic chr11:64965279(+) A-I      intronic chr11:64956621(+) A-I      intronic chr11:64975226(+) A-I      intronic chr11:64956594(+) A-I      intronic chr11:64961622(+) A-I      intronic chr11:64961563(+) A-I      intronic chr11:64958930(+) A-I      intronic chr11:64962617(+) A-I      intronic chr11:64961569(+) A-I      intronic chr11:64961533(+) A-I      intronic chr11:64961668(+) A-I      intronic chr11:64959567(+) A-I      intronic chr11:64965102(+) A-I      intronic chr11:64962752(+) A-I      intronic chr11:64960929(+) A-I      intronic chr11:64961282(+) A-I      intronic chr11:64968545(+) A-I      intronic chr11:64959591(+) A-I      intronic chr11:64965309(+) A-I      intronic chr11:64961619(+) A-I      intronic chr11:64961537(+) A-I      intronic chr11:64965724(+) A-I      intronic chr11:64974788(+) A-I      intronic chr11:64959577(+) A-I      intronic chr11:64975305(+) A-I      intronic chr11:64961204(+) A-I      intronic chr11:64956595(+) A-I      intronic chr11:64965171(+) A-I      intronic chr11:64961048(+) A-I      intronic chr11:64974745(+) A-I      intronic chr11:64965198(+) A-I      intronic chr11:64959585(+) A-I      intronic chr11:64975264(+) A-I      intronic chr11:64967590(+) A-I      intronic chr11:64965801(+) A-I      intronic chr11:64961469(+) A-I      intronic chr11:64965211(+) A-I      intronic chr11:64959540(+) A-I      intronic chr11:64960969(+) A-I      intronic chr11:64959651(+) A-I      intronic chr11:64965891(+) A-I      intronic chr11:64969433(+) A-I      intronic chr11:64961578(+) A-I      intronic chr11:64965823(+) A-I      intronic chr11:64966264(+) A-I      intronic chr11:64958927(+) A-I      intronic chr11:64965885(+) A-I      intronic chr11:64961519(+) A-I      intronic chr11:64965151(+) A-I      intronic chr11:64966486(+) A-I      intronic chr11:64961559(+) A-I      intronic chr11:64961327(+) A-I      intronic chr11:64959599(+) A-I      intronic chr11:64960933(+) A-I      intronic chr11:64958364(+) A-I      intronic chr11:64967650(+) A-I      intronic chr11:64961001(+) A-I      intronic chr11:64958349(+) A-I      intronic chr11:64974735(+) A-I      intronic chr11:64962760(+) A-I      intronic chr11:64965781(+) A-I      intronic chr11:64958313(+) A-I      intronic chr11:64965257(+) A-I      intronic chr11:64974851(+) A-I      intronic chr11:64959645(+) A-I      intronic chr11:64961562(+) A-I      intronic chr11:64958323(+) A-I      intronic chr11:64959575(+) A-I      intronic chr11:64958924(+) A-I      intronic chr11:64965239(+) A-I      intronic chr11:64967944(+) A-I      intronic chr11:64961639(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPN1	chr11:64959575(+) A-G intron -    22484847 chr11:64959577(+) A-G intron -    22484847 chr11:64959591(+) A-G intron -    22484847 chr11:64961469(+) A-G intron -    22484847 chr11:64961563(+) A-G intron -    22484847 chr11:64962751(+) A-G intron -    22484847 chr11:64962760(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPN1	chr11:64948689-64948690(+) m6A 5'UTR//intron       27773536 chr11:64949177-64949178(+) m6A 5'UTR//intron       24981863 chr11:64949248-64949249(+) m6A 5'UTR//intron       24981863 chr11:64949274-64949275(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863 chr11:64949452-64949453(+) m6A 5'UTR//exon//intron       25456834//24981863 chr11:64949469-64949470(+) m6A 5'UTR//exon//intron       25456834//24981863 chr11:64949970-64949971(+) m6A 5'UTR//intron       25456834 chr11:64950022-64950023(+) m6A 5'UTR//intron       25456834 chr11:64950058-64950059(+) m6A 5'UTR//intron       25456834 chr11:64950362-64950363(+) Y CDS//exon//intron       26075521 chr11:64955429-64955430(+) m6A 3'UTR//CDS//exon       24209618 chr11:64955468-64955469(+) m6A 3'UTR//CDS//exon       24209618 chr11:64955718-64955719(+) m6A exon//intron       24209618 chr11:64955733-64955734(+) m6A exon//intron       24209618 chr11:64955752-64955753(+) m6A exon//intron       24209618 chr11:64955801-64955802(+) m6A exon//intron       24209618 chr11:64955815-64955816(+) m6A exon//intron       24209618 chr11:64955828-64955829(+) m6A exon//intron       - chr11:64955898-64955899(+) m6A CDS//exon       - chr11:64955907-64955908(+) m6A CDS//exon       - chr11:64955922-64955923(+) m6A CDS//exon       - chr11:64956070-64956071(+) m6A CDS//exon       - chr11:64956135-64956136(+) m6A CDS//exon       - chr11:64956151-64956152(+) m6A CDS//exon       - chr11:64956208-64956209(+) m6A CDS//exon       - chr11:64970851-64970852(+) m6A exon//intron       - chr11:64972168-64972169(+) m6A CDS//exon       - chr11:64972222-64972223(+) m6A CDS//exon       - chr11:64973952-64973953(+) Y CDS//exon       26075521 chr11:64975556-64975557(+) m6A CDS//exon       - chr11:64975705-64975706(+) m6A CDS//exon       - chr11:64978764-64978765(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr11:64978934-64978935(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64978976-64978977(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64979038-64979039(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64979130-64979131(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr11:64979137-64979138(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr11:64979356-64979357(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:64979367-64979368(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:64979441-64979442(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CAPN1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: CAPN1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).