The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RRI00000122
RNA/Protein Symbol 1:HOTAIR
RNA/Protein Category 1: lncRNA
RNA/Protein Symbol 2: HOXD8 mRNA
RNA/Protein Category 2: mRNA
Validated Method: Immunoprecipitation, RT-PCR
Tissue:  
PMID: 17604720 
Detail description:

HOTAIR ncRNA may regulate gene expression in HOX loci in cis or trans; alternatively, it may be the act of antisense transcription in the HOXC locus rather than the ncRNA itself that has a functional role in gene regulation. depletion of HOTAIR lead to dramatic transcriptional activation of the HOXD locus on chromosome 2 spanning over 40 Kb, including HOXD8, HOXD9, HOXD10, HOXD11, and multiple ncRNAs (Fig. 5a, b, Supplementary Fig. 7). 

The Predicated Binding Sites between HOTAIR and HOXD8
By miRanda Structure Match Score Energy Score HOTAIR Location HOXD8 Location
The Predicated Binding Sites between HOTAIR and HOXD8
By RIsearch Structure HOTAIR Location HOXD8 Location Score 
Query:    3' GGUGGUUUUAUGCAUAAAUAAAGUUUUACAUGUGGUGAAU 5'
          ||:|:      ||||       |: ::||| |:: || |:
Target:   5' CCGCUC-----CGUAA---AAGCGUGGUGU-CGUGACGUG 3'
2320-2359 4-34 -11.13
The Predicated Binding Sites of HOXD8
RBPBD 

					

					

						RsiteDB
						
					

						BindN
						
							 

								
					

					

						BindN+
						
							 

								
					

					

					    RNAbindR
						
                              
	 
								
					

					

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	  The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
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The 'First Neighbour' represents the sub-network of direct interacting with the center node, 
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	  Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
	 


	  

	   
	
	

  





	

		

           			
				
	
                   The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
 
				   The Binding page: representing the predicted binding sites and/or constants.
 
				   The Network page: representing the interaction sub-network of interacting RNA/Protein.