Detail-Interactions: | |
RAID ID: | RPI00000648 |
---|---|
RNA/Protein Symbol 1: | KLK15 mRNA(m-Aco) |
RNA/Protein Category 1: | mRNA |
RNA/Protein Symbol 2: | ACO1(IRP1) |
RNA/Protein Category 2: | Protein |
Validated Method: | Immunoblotting, Immunoprecipitation |
Tissue: | HEK293 cells |
PMID: | 12855587 |
Detail description: | Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that affect the translation and stabilization of specific mRNAs by binding to stem-loop structures known as iron responsive elements (IREs). IREs are found in the 5`-untranslated region (UTR) of ferritin (Ft) and mitochondrial aconitase (m-Aco) mRNAs, and in the 3`-UTR of transferrin receptor (TfR) and divalent metal transporter-1 (DMT1) mRNAs. |
The Predicated Binding Sites between KLK15 mRNA and ACO1 | |||||
By miRanda | Structure | Match Score | Energy Score | KLK15 mRNA Location | ACO1 Location |
The Predicated Binding Sites between KLK15 mRNA and ACO1 | ||||
By RIsearch | Structure | KLK15 mRNA Location | ACO1 Location | Score |
The Predicated Binding Sites of ACO1 | |
RBPBD | |
RsiteDB | |
BindN |
>sp|P21399|ACOC_HUMAN Cytoplasmic aconitate hydratase OS=Homo sapiens GN=ACO1 PE=1 SV=3 Sequence: MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI Prediction: ------------------++-------+-+++-+-----+-------+------------ Confidence: 634789599889756234664427525435853942539599968796589677924468 Sequence: ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA Prediction: ------------------+--+------------------+---++---+--+------- Confidence: 569988583352372746447788879937858999888754465554353367348769 Sequence: DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV Prediction: -------------++-++++--------+-+-+--------------------+------ Confidence: 899997684523466458552326425362646456836823643692853665568359 Sequence: NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP Prediction: ------+----------------+-+---------------------------------- Confidence: 596399699985662235535454262224968988785885685769978737936998 Sequence: QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC Prediction: -----+---+-----+---------+--+------------------------------- Confidence: 587835644563247433576848253872856772897999687738257527277367 Sequence: PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE Prediction: -----+---------------++-+-+++--+-+---------+---------------- Confidence: 664665676889989394265552734565246623936687858745333434745995 Sequence: LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT Prediction: ----------+++++++-+-------+--------++--+------------+------- Confidence: 978347645276799662676523524664347657533666375453235444573865 Sequence: EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY Prediction: ---------------+-+++++-+---------+-------------+-+-+--+----- Confidence: 783684838857882726675525867775656528637685965495253523725622 Sequence: YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG Prediction: ----------------------------------------------------+-++++-- Confidence: 294546745393399779883756246622335558996992486787876462586423 Sequence: RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE Prediction: +--++++-++--+-----------+-+----------+-+--+---------+------- Confidence: 852556947855567699948764466537627663554842587957946347652685 Sequence: RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK Prediction: ---------------------------+---+------++++-+---------------+ Confidence: 264883899258453972637544655522546585327689382366667958462245 Sequence: SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA Prediction: ---------------+--------+--+-++-+++-++++-+-++-+++++++-+----- Confidence: 258695999687425524472362634926624974548545274466878983723659 Sequence: RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR Prediction: +-+----+---+---++--++----------------+-+-----------+-+++++++ Confidence: 665363857735573544254625327799999987553525576999776456656779 Sequence: DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP Prediction: ++--+----------------+--+------------------------+-+-+------ Confidence: 563558657889376673325652742755788869637376375564462426248896 Sequence: ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK Prediction: ---+---+---+--+-+--+------------------------+---+ Confidence: 5565325573665363725457729826979459957788246962576 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
BindN+ |
>sp|P21399|ACOC_HUMAN Cytoplasmic aconitate hydratase OS=Homo sapiens GN=ACO1 PE=1 SV=3 Sequence: MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI Prediction: -+----------------+++-+----------+-+++-+----+--+------------ Confidence: 132336289778443232543335328778345644436444924793498246825448 Sequence: ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA Prediction: -------------------------+--+--+--------+------++--++------- Confidence: 646745542775997868356145735642535567636645341225323375237659 Sequence: DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV Prediction: -------------+--------------+------------------+---------+-- Confidence: 785952453614241625887989967732374567924864651673422332215523 Sequence: NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP Prediction: +-----------------------+++++--+----------+----------------- Confidence: 366369596788655368868362588451473511631531422236969432823457 Sequence: QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC Prediction: -----+---------+-+----------+-------------------------+--+-- Confidence: 325385521372224434365649615852313121483644654347247217342623 Sequence: PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE Prediction: -----+------------------+----------------------------------- Confidence: 513354335577666267163424643226458665978889749845687578698696 Sequence: LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT Prediction: ----------+++++++-+----------------------------------------- Confidence: 839638654653377551467623484887899996575275386562446857654867 Sequence: EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY Prediction: ---------------+++++++-----------++------+++++-----++++----- Confidence: 787772846735644646575421517356455632211114333561543464724718 Sequence: YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG Prediction: -----------------------+-+-++-----------------------+++++--+ Confidence: 398698987896365977872334243451325668788975888799974268698116 Sequence: RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE Prediction: +-++--+--+--+-----------+----------------+------------------ Confidence: 816811721621638227846764482557448655553123254834732238896999 Sequence: RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK Prediction: -----------------------------------------+-+---------------- Confidence: 498988787476366976656443899775655688986423543551353868777564 Sequence: SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA Prediction: ------------------+-+---------+---------------+-++-++-+----- Confidence: 665792889399558412343242164224324225533677435532331852625249 Sequence: RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR Prediction: +----+--------------------------------+--------------++-++++ Confidence: 441225717613353752264438569988997866314337787898777446516758 Sequence: DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP Prediction: -+-------------------+--+++--++----------------------------- Confidence: 152439334537173541123621547124356558588799798887956784879899 Sequence: ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK Prediction: -----------+----------------------------++--++--+ Confidence: 7694868795935426247686919739958946225223543746377 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
RNAbindR |
>P21399|ACO1 Sequence: MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI Prediction: --+----------------+-+-----------++-++-++---+---+----------- Confidence: 247332400000012124361530110021233864780861135104502321130330 Sequence: ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA Prediction: --------------+-++++-+---+--++--------+--+---+--+--++--+---- Confidence: 141011111122125357853934171367433444235146304611523860462210 Sequence: DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV Prediction: -----+----++-----+----------+++-++-++++-++-----+--+--+++++-- Confidence: 124147413365144035000100032276638545888467213216147438687734 Sequence: NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP Prediction: +--+--+----------------++-+++--+---+--++-++------+--+------- Confidence: 634620611300000000010135648672171126038536631210160252032001 Sequence: QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC Prediction: ---------+-++--++++--++--+--+++++++++---------------+-+--+-- Confidence: 202214124518744558712652183196569669544323410010110252533832 Sequence: PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE Prediction: ++------------------+-+-+----------+---++------------------- Confidence: 553444113210000001238253613340113115142552110000000110010000 Sequence: LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT Prediction: --------+-+++++++++----------------------------------------- Confidence: 000100047368989875842343121121100011114344001000000000000201 Sequence: EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY Prediction: --------------++++++++++++--+++--++-------++++++++++++++---- Confidence: 114032131112427878888877551465642754242314557856877897874032 Sequence: YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG Prediction: ------------------------++-+++-------------------+-+++++++++ Confidence: 002102001000200210143313672686430010000000000000254669999556 Sequence: RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE Prediction: +-+++-+-+++-++-----++--++-----------++--------+++++-+------- Confidence: 827654745774873241266215711120123224673444233076567461100000 Sequence: RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK Prediction: -------------------------------------------+---+------------ Confidence: 000014222411200000011111000000000101000213064335103000001102 Sequence: SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA Prediction: -------------+--++--+++++++++++++++---+---++-+++++++++++-++- Confidence: 103303010211354466438867968886885554127223764699999996974881 Sequence: RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR Prediction: ++++++++-+++---+++--+++--+-----------+-------------+++++++++ Confidence: 989899692565204567445561463112222243051010020011104758997999 Sequence: DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP Prediction: ++++++++--+---+----+++-+++++-++----------------------------- Confidence: 897775652462345133265947776625542331211113113111043311000001 Sequence: ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK Prediction: -----+----------+------+----------+++++-+++-++--+- Confidence: 31144510121332417201010511410001348578649881893150 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
Pprint |
Sequence: MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI Prediction: --+---------------++-+--------------++-----+---+++---------- Confidence: 114221000010100010353430020010000201431111033105430222000000 Sequence: ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA Prediction: ------+--++---+----------+-------------+----+++++++++++----- Confidence: 001002533483016120200100052210000001010330104565543553322020 Sequence: DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV Prediction: ----+-+------+---------------------------------+++++++++---- Confidence: 010042500121251003002001111020000001002221111113665859542200 Sequence: NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP Prediction: -----------------------+++++++----------+-++---------------- Confidence: 100200010000002000000003759865300001002041530000000000000000 Sequence: QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC Prediction: -----+-+++---+++++----------+-++++++--+-------------+------- Confidence: 220008035523236639100000002152798959225100000000200250200000 Sequence: PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE Prediction: ----------------------+-+----------------------------------- Confidence: 100002002000000200000360412130000102100000000200000000000000 Sequence: LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT Prediction: ----------++-++----+---------------------------------------- Confidence: 010030000049399231130010000000321222221311221112111010011012 Sequence: EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY Prediction: -----++++-+-++++++++++---+-------+--+++++++++-------+-+----- Confidence: 102325774092667998999401053200001322444555646102000241711000 Sequence: YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG Prediction: ----------------------+-+++-+---+----------+++-+-+++++++++++ Confidence: 000000000000000000000072865031005132132222344615255899999999 Sequence: RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE Prediction: ++++++++++--------------------+--------+------+------------- Confidence: 999998976700000000000000100021400233223310102040001300000000 Sequence: RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK Prediction: -----------------------------------------------------------+ Confidence: 000000000000000000000000000210000000001010010012202100100233 Sequence: SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA Prediction: ---+-+---+++-+++-+------+---------+---+-+-+--+++--+++-+----- Confidence: 312305130554065314000011311200321230014240400335323543411211 Sequence: RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR Prediction: ---+-+------++++--+++------------------+-------------+++++++ Confidence: 122304211113454332534110000000000210200400030000000106489969 Sequence: DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP Prediction: ++----------------+++++++++++++----------------------------- Confidence: 541020111211001002754644687456400010100000000000110101000000 Sequence: ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK Prediction: ----++--++---+-----+-----------------+------+---- Confidence: 0113441245022631300400000010000000201710021053002 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.