| Detail: | |
| ncRNA Symmbol: | miR-126 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | SOX2 |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | hepatocellular carcinoma cell |
| PMID: | 25585946 |
| Detail Description: | MiR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2. Further luciferase assays, mRNA and protein assays consistently validated the target role of Sox2. Through restoring the expression of Sox2 in miR-126-transfected HepG2 cells, we found that overexpression of Sox2 could partially abrogate the miR-126-mediated suppression of cell growth. Thus, our data identified miR-126 as a tumor suppressor in HCC through, at least partially by targeting Sox2. This may provide novel diagnostic and therapeutic options for human HCC in future. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.