| Detail: | |
| ncRNA Symmbol: | miR-10b |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | TFAP2C |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | up |
| Species: | Homo sapiens |
| Tissue: | nonneoplastic brain tissue and glioma cells |
| PMID: | 21471404 |
| Detail Description: | We show that inhibition of miR-10b, a miRNA not expressed in human brain and strongly upregulated in both low-grade and high-grade gliomas, reduces glioma cell growth by cell-cycle arrest and apoptosis. These cellular responses are mediated by augmented expression of the direct targets of miR-10b, including BCL2L11/Bim, TFAP2C/AP-2¦Ã, CDKN1A/p21, and CDKN2A/p16, which normally protect cells from uncontrolled growth. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.