The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:miR-199a
ncRNA Category:miRNA
Interaction Gene Symbol: SIRT1
Death Pathway:apoptosis
Expression Direction of ncRNA:down
Species:Homo sapiens
Tissue:
PMID: 22811431
Detail Description:

In addition to miR-34a, miR-199a has also been associated with SIRT1 regulation. Knockdown of miR-199a results in the upregulation of SIRT1 and HIF1¦Á (271). As this report found that miR-199a levels were decreased in cardiac myocytes upon hypoxia, the data indicate that SIRT1 is important for hypoxic damage 

Select the ncRNA symbol and transcript of gene
Mature of miR-199a    Transcript of SIRT1    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.