Basic Information
| RNALocate ID: | RLID:00021648 |
| RNA Symbol: | NUMB |
| Localization: | Ribosome-free cytosol |
RNA Information
| RNA Name: | NUMB |
| RNA ID: | NCBI:8650|Ensembl:ENSG00000133961 |
| RNA Category: | mRNA |
| Species: | Homo sapiens |
| Alias: | C14orf41|S171|c14_5527 |
Localization Information
| PubMed ID: | 24393600 |
| Tissue/Cell Line: | Colon cancer cells |
| Method: | Next-generation RNA sequencing |
| Description: | The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5.Overall, we consider clusters I, II and III as enriched in the nucleus; IV and V as enriched in the ribosome-free cytosol; and VI, VII, VIII, IX and X as enriched in the ribosomes. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:00021647 | Cytosol | Human myelogenous leukemia cell line (K-562) | 21613539 |
| RLID-D:00006776 | Chromatin | K562 cells | |
| RLID-D:00013248 | Cytosol | K562 cells | |
| RLID-D:00018163 | Membrane | HCC cell line (HepG2) | |
| RLID-D:00031095 | Nucleoplasm | K562 cells | |
| RLID-D:00039883 | Nucleus | HCC cell line (HepG2)|HeLa-S3 cells|K562 cells | |
| RLID-D:10016315 | Exosome | Blood |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | SNHG16 | Homo sapiens | RR01027543 |
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