Basic Information
RNALocate ID: | RLID:11002728 |
RNA Symbol: | hsa-miR-423-3p |
Localization: | Exosome |
RNA Information
RNA Name: | hsa-miR-423 |
RNA ID: | miRBase:MIMAT0001340 |
RNA Category: | miRNA |
Species: | Homo sapiens |
Localization Information
PubMed ID: | 20615901 |
Tissue/Cell Line: | Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) |
Method: | Microarray|RT-PCR |
Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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Description: | These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. |
Other Subcellular Localization
RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
RLID:01002262 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01002263 | Mitochondrion | Myotube | 27396686 |
RLID:01002264 | Mitochondrion | Skeletal muscle cells | 27563705 |
RLID:01002265 | Mitochondrion | Skeletal muscle myoblasts | 21637849 |
RLID:01002266 | Mitochondrion | Cell line (HEK-293|HeLa) | 22984580 |
RLID:01002267 | Nucleus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:11002726 | Exosome | Human cervical carcinoma cell line (HeLa|SiHa) | 25760330 |
RLID:11002727 | Exosome | Serum | 18589210 |
RLID:11002729 | Exosome | Brain tissue | 23382797 |
RLID:11002730 | Exosome | Plasma | 23663360 |
RLID:11002731 | Extracellular vesicle | HEK-293T cells | 22849433 |
RLID:11002732 | Microvesicle | Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) | 20615901 |
RLID:11002733 | Microvesicle | Plasma | 23077538 |
RLID:11002734 | Microvesicle | Seminal plasma | 23539611 |
RLID-D:11000136 | Exosome | Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue | |
RLID-D:11000447 | Microvesicle | Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
Resource | RNA Symbol | Disease | Link |
MNDR | hsa-miR-423-3p | Splenic marginal zone lymphoma | MNDR-E-MI-48463 |
MNDR | hsa-miR-423-3p | Uterine corpus endometrial carcinoma | MNDR-E-MI-48464 |
MNDR | hsa-miR-423-3p | Lymphoma | MNDR-E-MI-48465 |
MNDR | hsa-miR-423-3p | Lymphoma non-hodgkin | MNDR-E-MI-48466 |
MNDR | hsa-miR-423-3p | Estrogen-receptor positive breast cancer | MNDR-E-MI-48467 |
MNDR | hsa-miR-423-3p | Progesterone-receptor positive breast cancer | MNDR-E-MI-48468 |
MNDR | hsa-miR-423-3p | Her2-receptor positive breast cancer | MNDR-E-MI-48469 |
MNDR | hsa-miR-423-3p | Dermatomyositis | MNDR-E-MI-48470 |
MNDR | hsa-miR-423-3p | Prostate cancer | MNDR-E-MI-48471 |
MNDR | hsa-miR-423-3p | Gastric cancer | MNDR-E-MI-48472 |
MNDR | hsa-miR-423-3p | Gastric lymphoma | MNDR-E-MI-48473 |
MNDR | hsa-miR-423-3p | Alzheimer disease | MNDR-E-MI-48474 |
MNDR | hsa-miR-423-3p | Intracranial aneurysm | MNDR-E-MI-48475 |
MNDR | hsa-miR-423-3p | Urinary bladder cancer | MNDR-E-MI-48476 |
MNDR | hsa-miR-423-3p | Polycystic ovary syndrome | MNDR-E-MI-48477 |
MNDR | hsa-miR-423-3p | Muscular dystrophy duchenne | MNDR-E-MI-48478 |
MNDR | hsa-miR-423-3p | Primary biliary cirrhosis | MNDR-E-MI-48479 |
MNDR | hsa-miR-423-3p | Cardiovascular disease | MNDR-E-MI-48480 |
MNDR | hsa-miR-423-3p | Lung cancer | MNDR-E-MI-48481 |
MNDR | hsa-miR-423-3p | Parkinson disease | MNDR-E-MI-48482 |
MNDR | hsa-miR-423-3p | Breast cancer | MNDR-E-MI-48483 |
MNDR | hsa-miR-423-3p | Malignant mesothelioma | MNDR-E-MI-48484 |
MNDR | hsa-miR-423-3p | Pancreatic cancer | MNDR-E-MI-48485 |
MNDR | hsa-miR-423-3p | Melanoma | MNDR-E-MI-48486 |
MNDR | hsa-miR-423-3p | Rectum adenocarcinoma | MNDR-E-MI-48487 |
MNDR | hsa-miR-423-3p | Colon cancer | MNDR-E-MI-48488 |
MNDR | hsa-miR-423-3p | Colon adenocarcinoma | MNDR-E-MI-48489 |
MNDR | hsa-miR-423-3p | Relapsing-remitting multiple sclerosis | MNDR-E-MI-48490 |
MNDR | hsa-miR-423-3p | Familial ovarian cancer | MNDR-E-MI-48491 |
MNDR | hsa-miR-423-3p | Prostate adenocarcinoma | MNDR-E-MI-48492 |
MNDR | hsa-miR-423-3p | Laryngeal carcinoma | MNDR-E-MI-48493 |
MNDR | hsa-miR-423-3p | Carcinoma ductal breast | MNDR-E-MI-48494 |
MNDR | hsa-miR-423-3p | Glioblastoma | MNDR-E-MI-48495 |
MNDR | hsa-miR-423-3p | Glioma | MNDR-E-MI-48496 |
MNDR | hsa-miR-423-3p | Amyotrophic lateral sclerosis | MNDR-E-MI-48497 |
MNDR | hsa-miR-423-3p | Epilepsy temporal lobe | MNDR-E-MI-48498 |
MNDR | hsa-miR-423-3p | Osteosarcoma | MNDR-E-MI-48499 |
MNDR | hsa-miR-423-3p | Inclusion body myositis | MNDR-E-MI-48500 |
MNDR | hsa-miR-423-3p | Middle cerebral artery infarction | MNDR-E-MI-48501 |
MNDR | hsa-miR-423-3p | Gastric adenocarcinoma | MNDR-E-MI-48502 |
MNDR | hsa-miR-423-3p | Lung squamous cell carcinoma | MNDR-E-MI-48503 |
MNDR | hsa-miR-423-3p | Non-small cell lung adenocarcinoma | MNDR-E-MI-48504 |
MNDR | hsa-miR-423-3p | Lung adenocarcinoma | MNDR-E-MI-48505 |
MNDR | hsa-miR-423-3p | Thyroid carcinoma | MNDR-E-MI-48506 |
MNDR | hsa-miR-423-3p | Bladder urothelial carcinoma | MNDR-E-MI-48507 |
MNDR | hsa-miR-423-3p | Pancreatic adenocarcinoma | MNDR-E-MI-48508 |
MNDR | hsa-miR-423-3p | Myasthenia gravis autoimmune experimental | MNDR-E-MI-48509 |
MNDR | hsa-miR-423-3p | Carcinoma renal cell | MNDR-E-MI-48510 |
MNDR | hsa-miR-423-3p | Kidney renal papillary cell carcinoma | MNDR-E-MI-48511 |
MNDR | hsa-miR-423-3p | Clear cell renal cell carcinoma | MNDR-E-MI-48512 |
MNDR | hsa-miR-423-3p | Chromophobe renal cell carcinoma | MNDR-E-MI-48513 |
MNDR | hsa-miR-423-3p | Cholangiocarcinoma | MNDR-E-MI-48514 |
MNDR | hsa-miR-423-3p | Esophageal cancer | MNDR-E-MI-48515 |
MNDR | hsa-miR-423-3p | Liver cirrhosis | MNDR-E-MI-48516 |
MNDR | hsa-miR-423-3p | Oncocytoma | MNDR-E-MI-48517 |
MNDR | hsa-miR-423-3p | Synovial sarcoma | MNDR-E-MI-48518 |
MNDR | hsa-miR-423-3p | Head and neck squamous cell carcinoma | MNDR-E-MI-48519 |
MNDR | hsa-miR-423-3p | Fibromyalgia | MNDR-E-MI-48520 |
MNDR | hsa-miR-423-3p | Encephalomyelitis | MNDR-E-MI-48521 |
MNDR | hsa-miR-423-3p | Breast invasive carcinoma | MNDR-E-MI-48522 |
MNDR | hsa-miR-423-3p | Hepatocellular carcinoma | MNDR-E-MI-48523 |
MNDR | hsa-miR-423-3p | Familiar ovarian carcinoma | MNDR-E-MI-48524 |
MNDR | hsa-miR-423-3p | B-cell lymphoma | MNDR-E-MI-48525 |
MNDR | hsa-miR-423-3p | Rheumatoid arthritis | MNDR-E-MI-48526 |
MNDR | hsa-miR-423-3p | T-cell leukemia | MNDR-E-MI-48527 |
MNDR | hsa-miR-423-3p | Malignant pleural mesothelioma | MNDR-E-MI-48528 |
MNDR | hsa-miR-423-3p | Barrett's adenocarcinoma | MNDR-E-MI-48529 |
MNDR | hsa-miR-423-3p | Burkitt lymphoma | MNDR-E-MI-48530 |
MNDR | hsa-miR-423-3p | Tonsil cancer | MNDR-E-MI-48531 |
MNDR | hsa-miR-423-3p | Neuromyelitis optica | MNDR-E-MI-48532 |
MNDR | hsa-miR-423-3p | Skin cutaneous melanoma | MNDR-E-MI-48533 |
MNDR | hsa-miR-423-3p | Skin melanoma | MNDR-E-MI-48534 |
MNDR | hsa-miR-423-3p | Colorectal cancer | MNDR-E-MI-48535 |
MNDR | hsa-miR-423-3p | Epstein-barr virus infections | MNDR-E-MI-48536 |
MNDR | hsa-miR-423-3p | Peripheral nerve injuries | MNDR-E-MI-48537 |
MNDR | hsa-miR-423-3p | Chronic pain | MNDR-E-MI-48538 |
MNDR | hsa-miR-423-3p | Stroke lacunar | MNDR-E-MI-48539 |
MNDR | hsa-miR-423-3p | Barrett's carcinogenesis | MNDR-E-MI-48540 |
MNDR | hsa-miR-423-3p | High grade dysplastic nodule | MNDR-E-MI-48541 |
RNA Interaction Information
Resource | RNA Symbol | Species | Link | RNALocate ID |
RNAInter | BCL2L11 | Homo sapiens | RR00219397 |
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