Basic Information
RNALocate ID: RLID:01001666
RNA Symbol: hsa-miR-221-3p
Localization: Cytoplasm
RNA Information
RNA Name: hsa-miR-221
RNA ID: miRBase:MIMAT0000278
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 21695135
Tissue/Cell Line: Cell line (HeLa)
Method: Microarray

Heatmap showing the 57 miRNAs differentially expressed in HeLa cells from mitochondrial and cytosolic RNA. Three independent microarray profiling experiments (microarray n1, n2 and n3) are shown and reproducibly revealed 13 miRNAs enriched in mitochondrial RNA.

Originally published in PLoS One. Bandiera S, et al, 2011. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001665 Cytoplasm Neural progenitor cells 21363885
RLID:01001667 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001668 Mitochondrion HEK-293 cells|HeLa cells|Myotube 27396686
RLID:01001669 Mitochondrion Skeletal muscle myoblasts 21637849
RLID:01001670 Mitochondrion Cell line (HEK-293|HeLa) 22984580
RLID:01001671 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001672 Nucleolus Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001673 Nucleus Nasopharyngeal carcinoma cells 20498841
RLID:11001529 Exosome Primary dendritic cells|T cell line (J77) 21505438
RLID:11001530 Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr) 22895844
RLID:11001531 Exosome Brain tissue 23382797
RLID:11001532 Exosome Plasma 23663360
RLID:11001533 Exosome Human mast cell line (HMC-1) 24009880
RLID:11001534 Exosome Colon cancer cell line (LIM1863) 25330373
RLID:11001535 Extracellular vesicle HEK-293T cells 22849433
RLID:11001536 Microvesicle Plasma 23077538
RLID:11001537 Microvesicle Seminal plasma 23539611
RLID-D:11000063 Exosome Blood|B lymphoblastoid cells|Breast tissue|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue
RLID-D:11000337 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-miR-221-3p Splenic marginal zone lymphoma MNDR-E-MI-30532
MNDR hsa-miR-221-3p Multiple sclerosis chronic progressive MNDR-E-MI-30533
MNDR hsa-miR-221-3p Oral squamous cell carcinoma MNDR-E-MI-30534
MNDR hsa-miR-221-3p Follicular cleaved lymphoma MNDR-E-MI-30535
MNDR hsa-miR-221-3p Medulloblastoma MNDR-E-MI-30536
MNDR hsa-miR-221-3p Small intestinal neuroendocrine tumor MNDR-E-MI-30537
MNDR hsa-miR-221-3p High-grade serous ovarian carcinoma MNDR-E-MI-30538
MNDR hsa-miR-221-3p Uterine corpus endometrial carcinoma MNDR-E-MI-30539
MNDR hsa-miR-221-3p Lymphoma MNDR-E-MI-30540
MNDR hsa-miR-221-3p Lymphoma non-hodgkin MNDR-E-MI-30541
MNDR hsa-miR-221-3p Estrogen-receptor negative breast cancer MNDR-E-MI-30542
MNDR hsa-miR-221-3p Progesterone-receptor negative breast cancer MNDR-E-MI-30543
MNDR hsa-miR-221-3p Her2-receptor positive breast cancer MNDR-E-MI-30544
MNDR hsa-miR-221-3p Acute promyelocytic leukemia MNDR-E-MI-30545
MNDR hsa-miR-221-3p Breast cancer luminal b MNDR-E-MI-30546
MNDR hsa-miR-221-3p Niemann-pick disease type c MNDR-E-MI-30547
MNDR hsa-miR-221-3p Precursor cell lymphoblastic leukemia-lymphoma MNDR-E-MI-30548
MNDR hsa-miR-221-3p Colorectal carcinoma MNDR-E-MI-30549
MNDR hsa-miR-221-3p Small intestine cancer MNDR-E-MI-30550
MNDR hsa-miR-221-3p Dermatomyositis MNDR-E-MI-30551
MNDR hsa-miR-221-3p Prostate cancer MNDR-E-MI-30552
MNDR hsa-miR-221-3p Prostate carcinoma MNDR-E-MI-30553
MNDR hsa-miR-221-3p Chronic lymphocytic leukemia MNDR-E-MI-30554
MNDR hsa-miR-221-3p Gastric cancer MNDR-E-MI-30555
MNDR hsa-miR-221-3p Gastric lymphoma MNDR-E-MI-30556
MNDR hsa-miR-221-3p Alzheimer disease MNDR-E-MI-30557
MNDR hsa-miR-221-3p Bladder cancer MNDR-E-MI-30558
MNDR hsa-miR-221-3p Dysautonomia familial MNDR-E-MI-30559
MNDR hsa-miR-221-3p Polycystic ovary syndrome MNDR-E-MI-30560
MNDR hsa-miR-221-3p Myotonic dystrophy MNDR-E-MI-30561
MNDR hsa-miR-221-3p Muscular dystrophy duchenne MNDR-E-MI-30562
MNDR hsa-miR-221-3p Facioscapulohumeral muscular dystrophy MNDR-E-MI-30563
MNDR hsa-miR-221-3p Head and neck cancer MNDR-E-MI-30564
MNDR hsa-miR-221-3p Leukemia MNDR-E-MI-30565
MNDR hsa-miR-221-3p Huntington disease MNDR-E-MI-30566
MNDR hsa-miR-221-3p Chorea MNDR-E-MI-30567
MNDR hsa-miR-221-3p Cardiovascular disease MNDR-E-MI-30568
MNDR hsa-miR-221-3p Carotid stenosis MNDR-E-MI-30569
MNDR hsa-miR-221-3p Brain cancer MNDR-E-MI-30570
MNDR hsa-miR-221-3p Lung cancer MNDR-E-MI-30571
MNDR hsa-miR-221-3p Down syndrome MNDR-E-MI-30572
MNDR hsa-miR-221-3p Parkinson disease MNDR-E-MI-30573
MNDR hsa-miR-221-3p Niemann-pick disease MNDR-E-MI-30574
MNDR hsa-miR-221-3p Major depressive disorder MNDR-E-MI-30575
MNDR hsa-miR-221-3p Basal-like breast cancer MNDR-E-MI-30576
MNDR hsa-miR-221-3p Vascular diseases MNDR-E-MI-30577
MNDR hsa-miR-221-3p Thyroid cancer MNDR-E-MI-30578
MNDR hsa-miR-221-3p Pituitary neoplasms MNDR-E-MI-30579
MNDR hsa-miR-221-3p Pancreatic cancer MNDR-E-MI-30580
MNDR hsa-miR-221-3p Hepatitis C MNDR-E-MI-30581
MNDR hsa-miR-221-3p Melanoma MNDR-E-MI-30582
MNDR hsa-miR-221-3p Atherosclerosis MNDR-E-MI-30583
MNDR hsa-miR-221-3p Nephroblastoma MNDR-E-MI-30584
MNDR hsa-miR-221-3p Colon cancer MNDR-E-MI-30585
MNDR hsa-miR-221-3p Essential thrombocythemia MNDR-E-MI-30586
MNDR hsa-miR-221-3p Ischemic attack transient MNDR-E-MI-30587
MNDR hsa-miR-221-3p Multiple sclerosis relapsing-remitting MNDR-E-MI-30588
MNDR hsa-miR-221-3p Ovarian cancer MNDR-E-MI-30589
MNDR hsa-miR-221-3p Prostate adenocarcinoma MNDR-E-MI-30590
MNDR hsa-miR-221-3p Carcinoma ductal breast MNDR-E-MI-30591
MNDR hsa-miR-221-3p Glioblastoma MNDR-E-MI-30592
MNDR hsa-miR-221-3p Astrocytoma MNDR-E-MI-30593
MNDR hsa-miR-221-3p Glioma MNDR-E-MI-30594
MNDR hsa-miR-221-3p Chordoma MNDR-E-MI-30595
MNDR hsa-miR-221-3p Amyotrophic lateral sclerosis MNDR-E-MI-30596
MNDR hsa-miR-221-3p Epilepsy temporal lobe MNDR-E-MI-30597
MNDR hsa-miR-221-3p Osteosarcoma MNDR-E-MI-30598
MNDR hsa-miR-221-3p Pediatric osteosarcoma MNDR-E-MI-30599
MNDR hsa-miR-221-3p Coronary artery disease MNDR-E-MI-30600
MNDR hsa-miR-221-3p Carotid artery thrombosis MNDR-E-MI-30601
MNDR hsa-miR-221-3p Inclusion body myositis MNDR-E-MI-30602
MNDR hsa-miR-221-3p Pancreatic ductal adenocarcinoma MNDR-E-MI-30603
MNDR hsa-miR-221-3p Liver cancer MNDR-E-MI-30604
MNDR hsa-miR-221-3p Uterine cancer MNDR-E-MI-30605
MNDR hsa-miR-221-3p Cervical adenocarcinoma MNDR-E-MI-30606
MNDR hsa-miR-221-3p Gastric adenocarcinoma MNDR-E-MI-30607
MNDR hsa-miR-221-3p Pituitary adenoma MNDR-E-MI-30608
MNDR hsa-miR-221-3p Lung squamous cell carcinoma MNDR-E-MI-30609
MNDR hsa-miR-221-3p Carcinoma lung non-small-cell MNDR-E-MI-30610
MNDR hsa-miR-221-3p Lung adenocarcinoma MNDR-E-MI-30611
MNDR hsa-miR-221-3p Adrenocortical carcinoma MNDR-E-MI-30612
MNDR hsa-miR-221-3p Thyroid carcinoma MNDR-E-MI-30613
MNDR hsa-miR-221-3p Papillary thyroid carcinoma MNDR-E-MI-30614
MNDR hsa-miR-221-3p Ovarian carcinoma MNDR-E-MI-30615
MNDR hsa-miR-221-3p Bladder urothelial carcinoma MNDR-E-MI-30616
MNDR hsa-miR-221-3p Pancreatic adenocarcinoma MNDR-E-MI-30617
MNDR hsa-miR-221-3p Cervical cancer MNDR-E-MI-30618
MNDR hsa-miR-221-3p Myasthenia gravis autoimmune experimental MNDR-E-MI-30619
MNDR hsa-miR-221-3p Carcinoma renal cell MNDR-E-MI-30620
MNDR hsa-miR-221-3p Chromophobe renal cell carcinoma MNDR-E-MI-30621
MNDR hsa-miR-221-3p Biliary tract cancer MNDR-E-MI-30622
MNDR hsa-miR-221-3p Intrahepatic cholangiocarcinoma MNDR-E-MI-30623
MNDR hsa-miR-221-3p Cholangiocarcinoma MNDR-E-MI-30624
MNDR hsa-miR-221-3p Esophageal cancer MNDR-E-MI-30625
MNDR hsa-miR-221-3p Oncocytoma MNDR-E-MI-30626
MNDR hsa-miR-221-3p Lung small cell carcinoma MNDR-E-MI-30627
MNDR hsa-miR-221-3p Gastric carcinoma MNDR-E-MI-30628
MNDR hsa-miR-221-3p Fibromyalgia MNDR-E-MI-30629
MNDR hsa-miR-221-3p Adenoma MNDR-E-MI-30630
MNDR hsa-miR-221-3p Breast invasive carcinoma MNDR-E-MI-30631
MNDR hsa-miR-221-3p Hepatocellular carcinoma MNDR-E-MI-30632
MNDR hsa-miR-221-3p Embryonal cancer MNDR-E-MI-30633
MNDR hsa-miR-221-3p B-cell lymphoma MNDR-E-MI-30634
MNDR hsa-miR-221-3p Rheumatoid arthritis MNDR-E-MI-30635
MNDR hsa-miR-221-3p T-cell leukemia MNDR-E-MI-30636
MNDR hsa-miR-221-3p Retinoblastoma MNDR-E-MI-30637
MNDR hsa-miR-221-3p Neuroblastoma MNDR-E-MI-30638
MNDR hsa-miR-221-3p Thyroid hurthle cell carcinoma MNDR-E-MI-30639
MNDR hsa-miR-221-3p Hodgkin lymphoma MNDR-E-MI-30640
MNDR hsa-miR-221-3p Burkitt lymphoma MNDR-E-MI-30641
MNDR hsa-miR-221-3p Cutaneous melanoma MNDR-E-MI-30642
MNDR hsa-miR-221-3p Acute myelocytic leukemia MNDR-E-MI-30643
MNDR hsa-miR-221-3p Colorectal cancer MNDR-E-MI-30644
MNDR hsa-miR-221-3p Nasopharynx carcinoma MNDR-E-MI-30645
MNDR hsa-miR-221-3p Type 2 diabetes mellitus MNDR-E-MI-30646
MNDR hsa-miR-221-3p Acute myocardial infarction MNDR-E-MI-30647
MNDR hsa-miR-221-3p Multiple myeloma MNDR-E-MI-30648
MNDR hsa-miR-221-3p Acute lymphoblastic leukemia MNDR-E-MI-30649
MNDR hsa-miR-221-3p Ependymoma MNDR-E-MI-30650
MNDR hsa-miR-221-3p Cardiomegaly MNDR-E-MI-30651
MNDR hsa-miR-221-3p Nasopharyngeal cancer MNDR-E-MI-30652
MNDR hsa-miR-221-3p Prostatic neoplasms MNDR-E-MI-30653
MNDR hsa-miR-221-3p Polymyositis MNDR-E-MI-30654
MNDR hsa-miR-221-3p Epstein-barr virus infections MNDR-E-MI-30655
MNDR hsa-miR-221-3p Mptp poisoning MNDR-E-MI-30656
MNDR hsa-miR-221-3p Intracranial hemorrhage hypertensive MNDR-E-MI-30657
MNDR hsa-miR-221-3p Stroke lacunar MNDR-E-MI-30658
MNDR hsa-miR-221-3p Duke C MNDR-E-MI-30659
MNDR hsa-miR-221-3p Tubulovillous adenoma MNDR-E-MI-30660
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter ADAM1A Homo sapiens RR00040682
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