Visualization
ViRBase provides visualization service online and the panel is easy to modulate. It allows user to observe and analyze ncRNA-associated interaction network by selecting interesting virus and Host. It needs some time to initialize of Cytoscape web tool, please wait a while. The Cytoscape web tool also needs the Flash Player installed and supported. In the bottom of visualization page, for EBV and KSHV-associated network (more than 5000 edges), we just represent the potential Gene Ontology functions and KEGG pathways by performing enrichment analysis.
The network is between virus and host: interactions
(Double click node or edge for the detail information)
:lncRNA 
:microRNA 
:protein-coding gene 
:other ncRNA Cytoscape Web works best with small- to medium-sized networks, generally with up to a few hundred nodes and edges, and the interactions can become sluggish around 2000 elements (nodes or edges)-800 nodes and 1200 edges. Hence, for EBV and KSHV-associated network (more than 5000 edges), we just represent the potential Gene Ontology functions and KEGG pathways by performing enrichment analysis.
Show EBV and KSHV Enrichment Annotation Result
Enrichment Annotation By DAVID(EBV and Homo sapiens): KEGG Pathway
| Category | Term | Count | P_value | FDR |
| KEGG_PATHWAY | hsa04115:p53 signaling pathway | 35 | 5.55E-011 | 6.85E-010 |
| KEGG_PATHWAY | hsa04110:Cell cycle | 48 | 2.66E-009 | 3.28E-008 |
| KEGG_PATHWAY | hsa05220:Chronic myeloid leukemia | 32 | 1.17E-007 | 1.45E-006 |
| KEGG_PATHWAY | hsa05210:Colorectal cancer | 34 | 1.95E-007 | 2.41E-006 |
| KEGG_PATHWAY | hsa05215:Prostate cancer | 35 | 2.82E-007 | 3.49E-006 |
| KEGG_PATHWAY | hsa05200:Pathways in cancer | 87 | 6.71E-007 | 8.29E-006 |
| KEGG_PATHWAY | hsa04310:Wnt signaling pathway | 48 | 1.95E-006 | 2.40E-005 |
| KEGG_PATHWAY | hsa05212:Pancreatic cancer | 29 | 2.11E-006 | 2.61E-005 |
| KEGG_PATHWAY | hsa04722:Neurotrophin signaling pathway | 41 | 4.29E-006 | 5.30E-005 |
Enrichment Annotation By DAVID(EBV and Homo sapiens): Gene Ontology
| Category | Term | Count | P_value | FDR |
| GOTERM_CC_FAT | GO:0031981~nuclear lumen | 396 | 1.01E-041 | 1.52E-040 |
| GOTERM_CC_FAT | GO:0070013~intracellular organelle lumen | 450 | 1.32E-038 | 1.99E-037 |
| GOTERM_CC_FAT | GO:0031974~membrane-enclosed lumen | 462 | 7.76E-038 | 1.16E-036 |
| GOTERM_CC_FAT | GO:0043233~organelle lumen | 453 | 5.51E-037 | 8.28E-036 |
| GOTERM_BP_FAT | GO:0045449~regulation of transcription | 626 | 1.60E-029 | 2.99E-028 |
| GOTERM_CC_FAT | GO:0005654~nucleoplasm | 252 | 5.47E-029 | 8.23E-028 |
| GOTERM_BP_FAT | GO:0006350~transcription | 515 | 1.51E-025 | 2.82E-024 |
| GOTERM_CC_FAT | GO:0005829~cytosol | 312 | 2.78E-020 | 4.19E-019 |
| GOTERM_BP_FAT | GO:0015031~protein transport | 224 | 3.01E-020 | 5.63E-019 |
Enrichment Annotation By DAVID(KSHV and Homo sapiens): KEGG Pathway
| Category | Term | Count | P_value | FDR |
| KEGG_PATHWAY | hsa05210:Colorectal cancer | 34 | 1.51E-009 | 1.85E-008 |
| KEGG_PATHWAY | hsa04144:Endocytosis | 54 | 1.04E-008 | 1.28E-007 |
| KEGG_PATHWAY | hsa05220:Chronic myeloid leukemia | 28 | 3.97E-007 | 4.88E-006 |
| KEGG_PATHWAY | hsa04115:p53 signaling pathway | 26 | 6.79E-007 | 8.34E-006 |
| KEGG_PATHWAY | hsa05200:Pathways in cancer | 75 | 1.04E-006 | 1.28E-005 |
| KEGG_PATHWAY | hsa04722:Neurotrophin signaling pathway | 37 | 2.11E-006 | 2.60E-005 |
| KEGG_PATHWAY | hsa04110:Cell cycle | 37 | 2.60E-006 | 3.20E-005 |
| KEGG_PATHWAY | hsa05213:Endometrial cancer | 21 | 3.99E-006 | 4.91E-005 |
| KEGG_PATHWAY | hsa03018:RNA degradation | 22 | 5.14E-006 | 6.31E-005 |
KSHV Enrichment Annotation By DAVID(KSHV and Homo sapiens): Gene Ontology
| Category | Term | Count | P_value | FDR |
| GOTERM_CC_FAT | GO:0031981~nuclear lumen | 342 | 2.21E-040 | 3.31E-039 |
| GOTERM_CC_FAT | GO:0070013~intracellular organelle lumen | 390 | 1.01E-038 | 1.52E-037 |
| GOTERM_CC_FAT | GO:0031974~membrane-enclosed lumen | 400 | 5.20E-038 | 7.79E-037 |
| GOTERM_CC_FAT | GO:0043233~organelle lumen | 394 | 7.90E-038 | 1.18E-036 |
| GOTERM_BP_FAT | GO:0006350~transcription | 447 | 9.03E-029 | 1.67E-027 |
| GOTERM_BP_FAT | GO:0045449~regulation of transcription | 525 | 2.05E-028 | 3.82E-027 |
| GOTERM_CC_FAT | GO:0005654~nucleoplasm | 213 | 8.39E-026 | 1.25E-024 |
| GOTERM_MF_FAT | GO:0003677~DNA binding | 452 | 1.16E-018 | 1.91E-017 |
| GOTERM_CC_FAT | GO:0044451~nucleoplasm part | 137 | 1.69E-017 | 2.53E-016 |