The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VHID00005719 |
|---|---|
| Virus: | Kaposi's sarcoma-associated herpesvirus(KSHV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Virus |
| ncRNA Category: | LncRNA |
| ncRNA Symbol: | PAN |
| Tissue: | HEK293 cell lines |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | PABPC1 |
| Expression Direction of Interactor: | - |
| Validated Method: | Luciferase assays,Immunoprecipitation,CLIP. |
| PMID: | 23077296 |
| Detailed Description: | We report that PABPC1 forms a complex with the Kaposi's sarcoma-associated herpesvirus(KSHV) ORF57 protein, which allows ORF57 to interact with a 9-nucleotide(nt) core element of KSHV polyadenylated nuclear(PAN) RNA, a viral long noncoding RNA(LncRNA), and increase PAN stability. These data indicate that PABPC1 is an important cellular target of viral ORF57 to directly upregulate PAN accumulation during viral lytic infection, and the ability of host PABPC1 to disrupt ORF57 expression is a strategic host counterbalancing mechanism. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.