The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | VHID00005714 |
---|---|
Virus: | Human immunodeficiency virus 1(HIV-1) |
Host Species: | Mus musculus |
ncRNA Source: | Virus |
ncRNA Category: | miRNA |
ncRNA Symbol: | nef |
Tissue: | MT-4 T cells |
Expression Direction of ncRNA: | - |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | Pparg |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Luciferase reporter, immunofluorescence, RT-PCR. |
PMID: | 21133815 |
Detailed Description: | One of the downstream targets of nef is PPAR-gamma and nef suppresses PPAR-gamma expression. In mice expressing nef miRNA, significant suppression of PPAR-gamma expression was seen in the intestinal adipose tissue. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.