The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | VHID00005713 |
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Virus: | Human immunodeficiency virus 1(HIV-1) |
Host Species: | Mus musculus |
ncRNA Source: | Virus |
ncRNA Category: | miRNA |
ncRNA Symbol: | hiv1-miR-N367 |
Tissue: | Jurkat T cells |
Expression Direction of ncRNA: | - |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | Tnip1 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Luciferase reporter, immunofluorescence, RT-PCR. |
PMID: | 21133815 |
Detailed Description: | Using EGFP and luciferase reporter constructs downstream of the nef target, nef miRNAs have been shown to downregulate nef expression in Jurkat T cells.Impressively,the nef miRNA (miR-N367) was effectively able to downregulate nef expression in the subcapsular regions of the spleen in mice, as determined by immunofluorescence and RT-PCR assays. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.