The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00012024 |
|---|---|
| Virus: | Dengue virus(DENV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-miR-30e-3p |
| Tissue: | human monocyte cell line U937 |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | mRNA |
| Interactor Symbol: | IFITM1 |
| Expression Direction of Interactor: | Upregualtion |
| Validated Method: | Quantitative real-time PCR(qRT-PCR), Cell viability analysis, Transient transfection and luciferase assay, Western blot analysis and immunofluorescence assays |
| PMID: | 25122182 |
| Detailed Description: | We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes(ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.