The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VHID00011994 |
|---|---|
| Virus: | Dengue virus(DENV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Virus |
| ncRNA Category: | LncRNA |
| ncRNA Symbol: | sfRNA |
| Tissue: | HuH-7 hepatocellular carcinoma cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | G3BP2 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | siRNA-mediated knockdown of gene expression, Polyribosome fractionation, ISRE-luciferase reporters |
| PMID: | 24992036 |
| Detailed Description: | Their antiviral activity was antagonized by the abundant DENV-2 non-coding subgenomic flaviviral RNA(sfRNA), which bound to G3BP1, G3BP2 and CAPRIN2, inhibited their activity and lead to profound inhibition of ISG mRNA translation. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.