The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HVID00011958 |
|---|---|
| Virus: | Human papillomavirus(HPV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | LncRNA |
| ncRNA Symbol: | ASncmtRNA-2 |
| Tissue: | HFK698 cells |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | E2 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | RT-PCR Amplification/In Situ Hybridization(ISH). |
| PMID: | 22539350 |
| Detailed Description: | Here we show that immortalization of HFK with HPV-16 or 18 causes down-regulation of the ASncmtRNAs and induces the expression of a new sense transcript named SncmtRNA-2. Transduction of HFK with both E6 and E7 is sufficient to induce expression of SncmtRNA-2. Moreover, E2 oncogene is involved in down-regulation of the ASncmtRNAs. Knockdown of E2 in immortalized cells reestablishes in a reversible manner the expression of the ASncmtRNAs, suggesting that endogenous cellular factors(s) could play functions analogous to E2 during non-HPV-induced oncogenesis.ASncmtRNAs Are Down-regulated in HPV-immortalized Cells As seen in Fig. 1. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.