The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HVID00011956 |
|---|---|
| Virus: | Human papillomavirus 16(HPV16) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-34a |
| Tissue: | Cervical |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | E6 |
| Expression Direction of Interactor: | - |
| Validated Method: | Retrovirus infection, Immunohistochemistry and microscopy, miRNA ligation assay, Northern blot analysis, and organotypic cultures, RNAi interference, Primary human keratinocytes, Western blot analysis, Cell transfection, Flow cytometry. |
| PMID: | 19258450 |
| Detailed Description: | The reduction of miR-34a expression in organotypic tissues derived from HPV-containing primary human keratinocytes correlates with the early productive phase and is attributed to the expression of viral E6, which destabilizes the tumor suppressor p53, a known miR-34a transactivator. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.