The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HVID00011928 |
|---|---|
| Virus: | Human immunodeficiency virus 1(HIV-1) |
| Host Species: | Rattus norvegicus |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | rno-let-7e |
| Tissue: | - |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | tat |
| Expression Direction of Interactor: | - |
| Validated Method: | Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. |
| PMID: | 18381601 |
| Detailed Description: | These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.