The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HVID00011875 |
|---|---|
| Virus: | Human T-cell leukemia virus 1(HTLV-1) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-146a |
| Tissue: | Peripheral blood mononuclear cells |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | Tax |
| Expression Direction of Interactor: | - |
| Validated Method: | Determination of provirus copy numbers, Analysis of effects of HTLV-1 proteins on endogenous microRNAs, Isolation of PBMC and lymphocyte populations, Quantification of mature microRNAs, Promoter analysis, Statistical analysis, MicroRNA primary transcript and mRNA detection. |
| PMID: | 19014482 |
| Detailed Description: | miR-146a expression was found to be directly stimulated by Tax via NF-KB-mediated transactivation of its promoter; a single NF-KB site proximal to the transcription start point was necessary and sufficient for this to happen. An in silico analysis of potential target genes revealed candidates that might be coregulated by two or more of the aforementioned overexpressed microRNAs. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.