The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HVID00011769 |
|---|---|
| Virus: | Ascoviruses |
| Host Species: | Drosophila melanogaster |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | Hz-miR24 |
| Tissue: | HzFB cells |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | mRNA |
| Interactor Symbol: | DdRPbeta |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Northern blot analyses, miRNA microarray analysis, Western blot analysis, RT-qPCR expression analysis, miRNA target studies, RNAi-mediated gene silencing. |
| PMID: | 19846520 |
| Detailed Description: | Here, we report changes in expression levels of host miRNAs upon ascovirus infection in an insect cell line and investigated the role of a host miRNA, Hz-miR24, in the host-virus system.The specific miRNA-target interactions were investigated and confirmed using the ectopic expression of Hz-miR24 and a green fluorescent protein-based reporter system. Our functional analysis of Hz-miR24 suggested that it plays an important role in interactions with HvAV-3e by downregulating viral DdRP and DdRPbeta transcripts later in infection. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.