The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011762 |
|---|---|
| Virus: | Vesicular stomatitis virus(VSV) |
| Host Species: | Cricetulus griseus |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | miR-706 |
| Tissue: | BHK cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | Caspase-9 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | MTT assay, fluorescent microscopy, miRCURY LNA miR microarray analysis, Annexin V-FITC/PI analysis, phase contrast microscopy, miRNA microarray, Overexpression and inhibition of miR-706 in BHK cells, Quantitative real-time PCR, Caspase activity assays. |
| PMID: | 20625776 |
| Detailed Description: | A laboratory-attenuated vesicular stomatitis virus induces apoptosis and alters the cellular microRNA expression profile in BHK cells. We further found that miR-706 inhibited VSV-induced apoptosis by decreasing caspase-3 and 10 activation, suggesting thatuction of miR-706 expression may be a novel strategy for survival of VSV, allowing it to escape the apoptosis response of the host.?ɡ. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.