The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011584 |
|---|---|
| Virus: | Influenza A virus H5N1(H5N1) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-141 |
| Tissue: | Epithelial cells |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | TGFB2 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Enzyme-linked immunosorbent assay (ELISA), qRT-PCR, gene expression profiles. |
| PMID: | 23663545 |
| Detailed Description: | Interestingly,we demonstrated that miR-141, which was more highly induced by H5N1 than by H1N1(p < 0.05), had an ability to suppress the expression of a cytokine - transforming growth factor(TGF)-beta2.Since TGF-beta2 is an important cytokine that can act as both an immunosuppressive agent and a potent proinflammatory molecule through its ability to attract and regulate inflammatory molecules, and previous report showed that only seasonal influenza H1N1(but not the other avian influenza subtypes) could induce a persistent expression of TGF-beta2, we speculate that the modulation of TGF-beta2 expression by different influenza subtypes via miR-141 might be a critical step for determining the outcome of either normal or excessive inflammation progression. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.