The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011565 |
|---|---|
| Virus: | Influenza A virus H1N1(H1N1) |
| Host Species: | Mus musculus |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | mmu-let-7g |
| Tissue: | A549 cells and primary cultured T cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | Interleukin 13 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | In silico identification of microRNA binding sites,Cell culture and transfection,Cell culture and transfection,RNA extraction and RT-PCR,RNA extraction and RT-PCR,RNA extraction and RT-PCR,Development of the ovalbumin-sensitized murine model of asthma and treatment of mice with let-7,MicroRNA design and delivery,Measurement of AHR,Measurement of cytokine (IL-4, IL-5, IL-13, and IFN-γ) levels in culture supernatant and lung homogenate and estimation of differential count in bronchoalveolar lavage fluid,Lung histology,Statistical analysis. |
| PMID: | 23731466 |
| Detailed Description: | Moreover,let-7g could inhibit the expression of IL-13, a key inducer of airway inflammation secreted by TH2 lymphocytes and other cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.