The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011218 |
|---|---|
| Virus: | Hepatitis C virus(HCV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-483-5p |
| Tissue: | Serum |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | ERK1 |
| Expression Direction of Interactor: | - |
| Validated Method: | miRecords, microarray hybridization, microRNA array. |
| PMID: | 23549102 |
| Detailed Description: | Serum miR-134, miR-320c and miR-483-5p were significantly upregulated during HCV infection. miR-320c and miR-483-5p were also upregulated in HCV- JFH1 infected cells and cell culture supernatant. In case of miR-483-5p, validated targets included SRF a modulator of VEGF signaling and ERK1 a member of the Ras-ERK intracellular signaling pathway that is modulated by HCV proteins such as NS5A. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.