The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | HHID00011184 |
---|---|
Virus: | Hepatitis C virus(HCV) |
Host Species: | Homo sapiens |
ncRNA Source: | Host |
ncRNA Category: | miRNA |
ncRNA Symbol: | hsa-mir-130a |
Tissue: | Hepatocytes and liver biopsy |
Expression Direction of ncRNA: | Upregulation |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | IFITM1 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Knockdown. |
PMID: | 22787204 |
Detailed Description: | Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.